Results 191 to 200 of about 3,045,873 (317)

Follow the data: tracking data quality and completeness in oncology real-world data. [PDF]

JAMIA Open
App SJ, Meyer AM, Silkensen S, Hudson C, Inman I, Niedner RH, Sincan M, Shaalan Beg M, Topaloglu U.   +8 more
europepmc   +1 more source

Translating real‐world evidence/real‐world data

Clinical and Translational Science
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real-World Data Screening and in Vitro Validation. [PDF]

Clin Transl Sci
Sakagami S, Yoshida Y, Uemura S, Kumamoto T, Tsukamoto R, Nishi T, Kawano S, Fukuoka K, Ino H, Hamamura K, Ohdo S, Matsunaga N.   +11 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Quantifying the Tolerability of Antipsychotic Treatment-Related Side Effects in Schizophrenia: A Survey Study of Patients and Caregiver Proxies

Patient Preference and Adherence
Melissa Culhane Maravic,1 Kelly Birch,1 Anh Thy H Nguyen,1 Alicia Subasinghe,2 Elizabeth Stafford,3 Christopher Zacker2 1Precision AQ, New York, NY, USA; 2Cerevel Therapeutics, Cambridge, MA, USA; 3National Alliance on Mental Illness, Arlington, VA ...
Maravic MC, Birch K, Nguyen ATH, Subasinghe A, Stafford E, Zacker C   +5 more
doaj  

Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real-World Data. [PDF]

Clin Transl Sci
Magagnoli J, Cummings TH, Wyatt MD, McInnes C, Ambati J, Sutton SS.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Analysis of Treatment Patterns for Mucosal Melanoma Using Real-World Data in the SEER-Medicare-Linked Database. [PDF]

Cancer Med
Zakeri M, Wagner S, Zhu X, Baser O.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source