Results 201 to 210 of about 3,045,873 (317)

Real-World Data on the Effectiveness of Immunotherapy on Advanced NSCLC: A Retrospective Cohort Study. [PDF]

Cancers (Basel)
Katsarolis A, Tapazidou-Spanoudi I, Kugiumtzis D, Pastelli N, Spyratos D, Manika K, Vagionas A, Lampaki S, Fountzilas E.   +8 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Cost implications of early treatment discontinuation in cancer: a real-world data analysis. [PDF]

Oncologist
Post HC, Opmeer K, Schutte T, Delsing MH, Timmers L, Hollak CEM, van Laarhoven HWM, Frederix GWJ.   +7 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A scoping review on using real-world data to evaluate the effectiveness of mHealth applications. [PDF]

NPJ Digit Med
Gehder S, Brückner S, Gilbert S, Goeldner M.   +3 more
europepmc   +1 more source

Editorial: Real-world data and real-world evidence in lung cancer

Frontiers in Oncology
Valerio Gristina, Chukwuka Eze
openaire   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Effectiveness and safety of mirikizumab in ulcerative colitis: real-world data from the Latium Net. [PDF]

BMJ Open Gastroenterol
Murgiano M, Balestrieri P, Calabrese E, Fiorino G, Festa S, Pugliese D, Di Vincenzo F, Puca P, Parello S, Vespasiano V, Colella A, Marafini I, Profeta F, Foscarini E, Papa A, Lopetuso LR, Monteleone G, Cicala M, Gasbarrini A, Laterza L, Scaldaferri F.   +20 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Risk of Safety Events in Vitiligo Patients: A Retrospective Real-World Data Study in the US. [PDF]

J Dermatol
Cook K, Elbuluk NM, Adiri R, Lejeune A, Edwards T, Gianfrancesco MA, Kelly SP, Lukic T, Nagy E, Kurosky SK, Napatalung L, Hamzavi I.   +11 more
europepmc   +1 more source