Results 191 to 200 of about 2,242,374 (316)

Advancing real-world evidence in Brazil: regulatory gaps and global lessons. [PDF]

Lancet Reg Health Am
Cézar de Aquino N, Reichert CO, Alberto de Padua Covas Lage L, Culler HF, Rosa Roitberg FS, Rocha V, Rocha Alves FN, Pereira J.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Social inequities and clinical outcomes in young women with cervical cancer: Real-world evidence. [PDF]

PLoS One
Cupertino Bérgomi L, de Souza Carvalho G, Zanetti de Albuquerque L, Gonçalves Kischinhevsky D, Dos Santos ALS, de Freitas Maciel L, Ávila Small I, Lopes da Silva J, de Melo AC.   +8 more
europepmc   +1 more source

Strengthening evidence-based medicine with real-world evidence

The Lancet Healthy Longevity, 2022
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

WCN25-52 EPIDEMIOLOGY OF IMMUNOGLOBULIN A NEPHROPATHY (IgAN) AND OCCURRENCE OF PROTEINURIA IN CHINA: EVIDENCE FROM SYSTEMATIC REVIEW AND META-ANALYSIS

Kidney International Reports
Zhaoxin Chen, Yilong Zhang, Wentian Lu, Jiaqi Kou, Jiaxi Zhu, Hema K. Gandhi, Sasikiran Nunna   +6 more
doaj   +1 more source

Real-world Evidence of Brodalumab Safety for the Treatment of Psoriasis. [PDF]

J Psoriasis Psoriatic Arthritis
Lebwohl M, Song EJ, Bhutani T, Green L, Jacobson A.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Initial Real-World Evidence for Lecanemab in the United States. [PDF]

Drugs Aging
Brixner DI, Zhao C, Toyosaki H, Frech FH, Rosenbloom MH.   +4 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source