Results 181 to 190 of about 1,338,680 (315)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Efficacy and Safety of Guselkumab in Real-World Evidence: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Dodero-Anillo JM, Fernandez-Pujol-Marzo M, Martinez MJP, Ruiz-Villaverde R, Armario-Hita JC.   +4 more
europepmc   +1 more source

When can real‐world data generate real‐world evidence?

Pharmacoepidemiology and Drug Safety, 2023
Motiur Rahman, Gerald Dal Pan, Peter Stein, Mark Levenson, Stefanie Kraus, Aloka Chakravarty, Donna R. Rivera, Richard Forshee, John Concato   +8 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Real World Evidence in Alopecia Areata: Current Management, Emerging Therapies and Future Challenges - A Narrative Review. [PDF]

J Inflamm Res
Khoda F, Chandidzura A, Sinclair R, Wall D, Meah N, Harries M.   +5 more
europepmc   +1 more source

A World Without Lead: Paving the Path to a Healthy, Productive Future

Despite robust evidence documenting the tragic and widespread consequences of lead exposure, the issue has received little attention from policy makers around the world. Recent calls to action by the G-7 have increased the visibility of this issue.
World Bank
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Real-world evidence of measurable residual disease assessment in multiple myeloma. [PDF]

Blood Adv
Cedena MT, Puig N, Paiva B, de la Puerta JE, Pérez-Montaña A, Casanova M, Breña J, García A, de Arriba F, Martínez-Chamorro C, Sirvent M, Blanchard MJ, Alonso R, Álvarez MÁ, Capote FJ, García-Sánchez R, Pérez JJ, Rodriguez-Otero P, Lahuerta JJ, Martínez-López J, Martínez-López J, Mateos MV, San-Miguel J.   +22 more
europepmc   +1 more source

Pharmacoepidemiology in the Era of Real-World Evidence [PDF]

Current Epidemiology Reports, 2017
openaire   +2 more sources