Results 181 to 190 of about 3,960,591 (302)

Translating real‐world evidence/real‐world data

Clinical and Translational Science
openaire   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Antipsychotic treatment patterns and cardiometabolic medicine use: current real-world evidence. [PDF]

Epidemiol Psychiatr Sci
Radha Krishnan RP, Zoega H, Buckley NA, Raubenheimer JE.   +3 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Applications of artificial intelligence for real-world evidence generation: a protocol for a living scoping review. [PDF]

BMJ Open
Oikonomidi T, Raad H, Diaz-Decaro J, Li H, Y Smith M, Rivera DR, Liu W, Soriano Gabarró M, Bennett D, Mack CD, Teltsch DY, Gerber JE, Bray B, Dickinson H, Jani M, Naidoo N.   +15 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

WCN25-52 EPIDEMIOLOGY OF IMMUNOGLOBULIN A NEPHROPATHY (IgAN) AND OCCURRENCE OF PROTEINURIA IN CHINA: EVIDENCE FROM SYSTEMATIC REVIEW AND META-ANALYSIS

Kidney International Reports
Zhaoxin Chen, Yilong Zhang, Wentian Lu, Jiaqi Kou, Jiaxi Zhu, Hema K. Gandhi, Sasikiran Nunna   +6 more
doaj   +1 more source

Mortality incidence in spondyloarthritis: real-world evidence using the TriNetX Global Collaborative Network. [PDF]

RMD Open
Llop M, Rodrigo-Parés A, Saus E, Moreno M, Arévalo M, Cabanillas M, Gratacós J, Calvet J.   +7 more
europepmc   +1 more source

Strengthening evidence-based medicine with real-world evidence

The Lancet Healthy Longevity, 2022
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source