Results 191 to 200 of about 3,960,591 (302)

Evaluation of bempedoic acid in elderly patients: real-world evidence from the REALIST study. [PDF]

Front Aging
Muscoli S, Di Marco E, Puttini F, Sposini Ghezzi S, Ifrim M, Amtaeh M, Renga EM, Cappello C, Barone G, Chiricolo G, Sangiorgi GM, Natale A, Della-Morte D.   +12 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Thromboembolic disease in testicular germ cell tumors-real-world evidence of three Portuguese institutions. [PDF]

Front Oncol
Albuquerque J, Oliveira M, Neto-Silva D, Margarido I, Correia J, Baptista C, Machete M, Bizarro R, Rato J, Godinho J, Teixeira JA, Passos-Coelho JL.   +11 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Real-World Evidence on Statin Use for Traumatic Brain Injury Associated Degenerative Neurological Disorders. [PDF]

Ther Clin Risk Manag
Lin YH, Tsai IJ, Chang YA, Huang CH, Chang CC.   +4 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Real-World Evidence on Mobile App-Supported Diabetes Management in Insulin-Treated Patients. [PDF]

J Diabetes Res
Roth L, Stein J, Schwarz PEH.
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence. [PDF]

Front Reprod Health
Méndez-Vidal C, Fernández-Sánchez M, Domínguez-Moreno M, García-Díaz L, Dopazo J, Antiñolo G.   +5 more
europepmc   +1 more source

Real World Evidence governance

Under the consortium agreement, clear data access rules and data transfer agreement rules will be ...
openaire   +1 more source