Results 51 to 60 of about 2,242,374 (316)

Correlation Between Early Time-to-Event Outcomes and Overall Survival in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Receiving Definitive Chemoradiation Therapy: Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
BackgroundOverall survival (OS) is the most patient-relevant outcome in oncology; however, in early cancers, large sample sizes and extended follow-up durations are needed to detect statistically significant differences in OS between interventions.
Christopher M. Black, Sam Keeping, Ali Mojebi, Karthik Ramakrishnan, Diana Chirovsky, Navneet Upadhyay, Dylan Maciel, Dieter Ayers   +7 more
doaj   +1 more source

Treatment pathways, economic burden and clinical outcomes in new users of inhaled corticosteroid/long-acting B2-agonist dual therapy with chronic obstructive pulmonary disease in a primary care setting in England: a retrospective cohort study

BMJ Open
Objective Management of chronic obstructive pulmonary disease (COPD) with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) improves lung function and health status and reduces COPD exacerbation risk versus monotherapy.
Victoria Banks, Robert Wood, Gema Requena, Alexandrosz Czira, Theo Tritton, Rosie Wild, Chris Compton, Afisi Ismaila   +7 more
doaj   +1 more source

Real-World Evidence of Omnipod® 5 Automated Insulin Delivery System Use in 69,902 People with Type 1 Diabetes

Diabetes Technology & Therapeutics
Background: The Omnipod® 5 Automated Insulin Delivery System was associated with favorable glycemic outcomes for people with type 1 diabetes (T1D) in two pivotal clinical trials.
Gregory P. Forlenza, D. Desalvo, G. Aleppo, E. Wilmot, Cari Berget, Lauren M. Huyett, Irene Hadjiyianni, Jose J. Mendez, L. Conroy, Trang T. Ly, J. Sherr   +10 more
semanticscholar   +1 more source

Metformin and Cancer: Solutions to a Real-World Evidence Failure.

Diabetes Care, 2023
The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention and treatment, which began in 2005 with an observational study that reported a reduction in cancer incidence among metformin users, generated extensive experimental,
O. Yu, S. Suissa
semanticscholar   +1 more source

Clinical and economic burden of pneumococcal disease in US adults aged 19–64 years with chronic or immunocompromising diseases: an observational database study

BMC Infectious Diseases, 2018
Background Despite the widespread availability of pneumococcal vaccines, rates of pneumococcal disease are disproportionately high in adults with chronic and immunocompromising conditions. This study investigated pneumococcal disease rates and associated
Dongmu Zhang, Tanaz Petigara, Xiaoqin Yang   +2 more
doaj   +1 more source

Review of real-world evidence of dual inhibition of VEGF-A and ANG-2 with faricimab in NAMD and DME

International Journal of Retina and Vitreous
Management of vitreoretinal disorders (e.g., neovascular age-related macular degeneration [nAMD] and diabetic macular edema [DME]) have assumed the standard therapy of lifelong anti-VEGF injections with drugs like aflibercept, brolucizumab, ranibizumab ...
Fernando M Penha, Maliha Masud, Zoha A. Khanani, Mathew J. Thomas, Rodney Fong, Kyler Smith, Avishay Chand, Majid Khan, G. Gahn, G. Melo, A. Khanani   +10 more
semanticscholar   +1 more source

Epidemiology, etiology and treatment of gastroparesis: real-world evidence from a large US national claims database.

Gastroenterology, 2021
BACKGROUND & AIMS While gastroparesis carries a considerable healthcare and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient ...
Y. Ye, Y. Yin, S. Huh, C. Almansa, D. Bennett, M. Camilleri   +5 more
semanticscholar   +1 more source

Communication and Language Profiles of Children Treated for Posterior Fossa Brain Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cognitive and language deficits are frequently reported sequelae of posterior fossa brain tumors (PFBT). Typically, delayed onset impedes prompt assessment and early intervention. This has devastating implications for quality of life.
Zara Sved, Meghan Hesse, Jennie Cusiter, Annabel Webb, Kimberley Docking   +4 more
wiley   +1 more source

Real-world study of patients with locally advanced HNSCC in the community oncology setting

Frontiers in Oncology, 2023
IntroductionThere is a need to understand the current treatment landscape for LA HNSCC in the real-world setting.MethodsThis retrospective study assessed real-world outcomes and treatment patterns of 1,158 adult patients diagnosed with locally advanced ...
Christopher M. Black, Karthik Ramakrishnan, Eric Nadler, Eric Nadler, Wan-Yu Tseng, Chuck Wentworth, John Murphy, Nicole Fulcher, Liya Wang, Melannie Alexander, Gregory Patton   +10 more
doaj   +1 more source

Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma.

Blood Advances, 2020
Tisagenlecleucel is a CD19 chimeric antigen receptor (CAR) T-cell therapy approved for treatment of pediatric and young adult patients with relapsed/refractory acute lymphoblastic leukemia (ALL) and adults with non-Hodgkin lymphoma (NHL).
M. Pasquini, Zhen-Huan Hu, K. Curran, T. Laetsch, F. Locke, R. Rouce, M. Pulsipher, C. Phillips, A. Keating, M. Frigault, Dana B. Salzberg, S. Jaglowski, Joshua P. Sasine, J. Rosenthal, M. Ghosh, D. Landsburg, S. Margossian, P. Martin, M. Kamdar, P. Hematti, S. Nikiforow, C. Turtle, M. Perales, Patricia Steinert, M. Horowitz, A. Moskop, L. Pacaud, Lan Yi, Raghav Chawla, E. Bleickardt, S. Grupp   +30 more
semanticscholar   +1 more source