Results 61 to 70 of about 2,242,374 (316)

The HIT Network for Children and Adolescents With CNS Tumors Facilitates Improvements of Diagnostic Assessments, Multimodal Treatments, Individual Counseling, and Research in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski, Michael C. Frühwald, Gudrun Fleischhack, Stephan Tippelt, Pablo Hernáiz‐Driever, Olaf Witt, Astrid Gnekow, Christof Kramm, Matthias Eyrich, Johannes E. A. Wolf, Hermann Müller, Carsten Friedrich, Uwe R. Kordes, Denise Obrecht‐Sturm, Petra Ketteler, Barbara von Zezschwitz, Pascal Johann, Dominik Sturm, Karoline Nemes, Stefan Schönberger, Till Milde, Brigitte Bison, Monika Warmuth‐Metz, Torsten Pietsch, Ulrich Schüller, Arend Koch, David Capper, Martin Hasselblatt, Christian Thomas, Christian Hagel, Stefan M. Pfister, Felix Sahm, David T. W. Jones, Martin U. Schuhmann, Jürgen Krauss, Pedram Emami, Ahmed El Damaty, Rolf D. Kortmann, Rudolf Schwarz, Jürgen Debus, Mechthild Krause, Fabian Pohl, Holger Ottensmeier, Lisa Bußenius, Katja Baust, Andreas Faldum, Cecile Ronckers, Desiree Grabow, Martin Benesch, Thomas Perwein, Karin Dieckmann, Irene Slavc, Johannes Gojo, Nicolas U. Gerber, André O. von Bueren, Katrin Scheinemann, Gabriele Calaminus, Beate Timmermann, Ulrich‐Wilhelm Thomale, Martin Mynarek   +59 more
wiley   +1 more source

FDA-authorized COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health system

medRxiv, 2021
Large Phase 3 clinical trials of the two FDA-authorized COVID-19 vaccines, mRNA-1273 (Moderna) and BNT162b2 (Pfizer/BioNTech), have demonstrated efficacies of 94.1% (n = 30,420, 95% CI: 89.3-96.8) and 95% (n = 43,448, 95% CI: 90.3-97.6) in preventing ...
C. Pawlowski, P. Lenehan, A. Puranik, V. Agarwal, A. Venkatakrishnan, M. Niesen, J. O’Horo, A. Virk, M. Swift, A. Badley, J. Halamka, V. Soundararajan   +11 more
semanticscholar   +1 more source

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study

Infectious Diseases and Therapy
Introduction This study evaluated the effectiveness of Moderna’s updated mRNA-1273 vaccine targeting the KP.2 variant, compared to people who did not receive any 2024–2025 COVID-19 vaccine, in preventing COVID-19-associated hospitalizations and medically-
Nevena Vicic, Alina Bogdanov, Zhe Zheng, Taylor Ryan, Ni Zeng, Keya Joshi, Tianyi Lu, Machaon Bonafede, Andre B. Araujo, Amanda Wilson   +9 more
doaj   +1 more source

Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence.

Journal of Allergy and Clinical Immunology, 2019
The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of
J. Bousquet, H. Schünemann, A. Togias, C. Bachert, Martina Erhola, P. Hellings, L. Klimek, O. Pfaar, D. Wallace, I. Ansotegui, I. Agache, A. Bedbrook, K. Bergmann, M. Bewick, P. Bonniaud, S. Bosnic‐Anticevich, I. Bossé, J. Bouchard, L. Boulet, J. Brożek, G. Brusselle, M. Calderón, W. Canonica, L. Caraballo, V. Cardona, T. Casale, L. Cecchi, D. Chu, E. Costa, Á. Cruz, W. Czarlewski, G. D'Amato, P. Devillier, M. Dykewicz, M. Ebisawa, Jean-Louis Fauquert, W. Fokkens, J. Fonseca, J. Fontaine, B. Gemicioğlu, R. V. van Wijk, T. Haahtela, S. Halken, D. Ierodiakonou, Tomohisa Iinuma, J. Ivancevich, M. Jutel, I. Kaidashev, M. Khaitov, O. Kalayci, Jörg Kleine Tebbe, M. Kowalski, P. Kuna, V. Kvedarienė, S. La Grutta, Désirée Larenas‐Linemann, S. Lau, D. Laune, L. Le, P. Lieberman, K. L. Lødrup Carlsen, O. Lourenço, G. Marien, P. Carreiro‐Martins, E. Mélen, E. Menditto, H. Neffen, G. Mercier, Ralph Mosgues, J. Mullol, A. Muraro, L. Namazova, E. Novellino, R. O'Hehir, Y. Okamoto, K. Ohta, Hae‐Sim Park, P. Panzner, G. Passalacqua, N. Pham‐Thi, D. Price, G. Roberts, N. Roche, C. Rolland, N. Rosário, D. Ryan, B. Samoliński, M. Sánchez-Borges, G. Scadding, M. Shamji, A. Sheikh, A. T. Bom, S. Toppila-Salmi, Ioana Tsiligianni, M. Valentín-Rostán, A. Valiulis, E. Valovirta, M. Ventura, S. Walker, S. Waserman, A. Yorgancioglu, T. Zuberbier   +101 more
semanticscholar   +1 more source

Biologics for severe asthma: The real-world evidence, effectiveness of switching, and prediction factors for the efficacy.

Allergology International, 2022
Biologics have been a key component of severe asthma treatment, and there are currently biologics available that target IgE, IL-5, IL-4/IL-13, and TSLP.
H. Nagase, M. Suzukawa, K. Oishi, K. Matsunaga   +3 more
semanticscholar   +1 more source

Imaging of High‐Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij, Catia Olianti, Herve Brisse, Pier Luigi Di Paolo, Maria Garganese, Tejas Kapadia, Jurgen Schaefer, Hugh Wallace, Simon Wan, Bart de Keizer, Irmina Sefic Pasic, Julian Rogasch   +11 more
wiley   +1 more source

Real‐world evidence for the long‐term effect of allergen immunotherapy: Current status on database‐derived European studies

Allergy. European Journal of Allergy and Clinical Immunology, 2022
Randomized controlled trials (RCTs) are the gold‐standard for benefit–risk assessments during drug approval processes. Real‐word data (RWD) and the resulting real‐world evidence (RWE) are becoming increasingly important for assessing the effectiveness of
C. Vogelberg, L. Klimek, B. Brüggenjürgen, M. Jutel   +3 more
semanticscholar   +1 more source

Effects of Cancer Treatment on Somatosensory and Nociceptive Processing in Children and Adolescents: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Chemotherapy‐induced peripheral neuropathy remains a major complication in pediatric cancer, with disrupted somatosensory and nociceptive processing being a key aspect. This review synthesizes empirical studies on alterations in somatosensory and nociceptive processing in children and adolescents with cancer.
Julia Schweiger, Laura Walz, Michael C. Frühwald, Stefan Lautenbacher, Miriam Kunz   +4 more
wiley   +1 more source

Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study

BMC Psychiatry
Objectives To examine the prevalence of comorbidities and the use of psychiatric comedication among individuals in medical treatment for attention deficit hyperactivity disorder (ADHD), in comparison to a matched control group from the general population.
Maria Vestergaard, Rikke Faergemann Hansen, Per Hove Thomsen, Andreas Hoiberg Bentsen, Anne Cathrine Falch-Joergensen   +4 more
doaj   +1 more source