Results 51 to 60 of about 26,300 (250)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Impact of Powertrain Type and Thermal Management on Real Driving Emissions of HEVs and GDI Vehicles

Vehicles
The transport sector plays a significant role in air pollution, and real-world emissions measurements are becoming increasingly important. In this study, emissions from a turbocharged, direct-injection gasoline internal combustion engine (ICE) vehicle ...
Zoltán Szávicza, Dániel Pup, Péter Raffai, Zsolt Maldrik   +3 more
doaj   +1 more source

Assessment of real driving emissions via portable emission measurement system [PDF]

IOP Conference Series: Materials Science and Engineering, 2017
The European Commission approved a so-called Real Driving Emission (RDE) test in response to the criticisms to the current driving cycle used at chassis dyno for homologation purpose (NEDC): it is considered outdated and misleading since air pollutants in real driving conditions are considerably higher than the certification thresholds.
A Clenci, V Sălan, R Niculescu, V Iorga-Simăn, C Zaharia   +4 more
openaire   +1 more source

Investigation on An Innovative Hydrocarbon Sensor for Real Drive Emissions

Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 2021
European law specifies limit values (and test methods) for pollutant emissions from light duty vehicles and heavy-duty engines including carbon monoxide (CO), hydrocarbons (HC), nitrogen oxide (NOx) and particulates, which are considered dangerous to human health.
null Muhammad Nor Azril Zulkafli, null Norazlianie Sazali, null Saiful Anwar Che Ghani, null Maurice Kettner   +3 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Energy management strategies for hybrid diesel vehicles by dynamic planning embedded in real-world driving emission model

Case Studies in Thermal Engineering
The optimization of energy management strategy for hybrid vehicles is often based on engine steady performance data and the standard driving cycle conditions in the laboratory.
Yingzhang Wang, Li Zhang, Yang Chen, Chaokai Li, Baocheng Du, Jinlin Han   +5 more
doaj   +1 more source

ParcEMon: IoT Platform for Real-Time Parcel Level Last-Mile Delivery Greenhouse Gas Emissions Reporting and Management

Sensors, 2022
Transport is Australia’s third-largest source of greenhouse gases accounting for around 17% of emissions. In recent times, and particularly as a result of the global pandemic, the rapid growth within the e-commerce sector has contributed to last-mile ...
Ali Yavari, Hamid Bagha, Harindu Korala, Irfan Mirza, Hussein Dia, Paul Scifleet, Jason Sargent, Mahnaz Shafiei   +7 more
doaj   +1 more source

Testing and evaluating real driving emissions with PEMS

Combustion Engines, 2018
Testing of real driving emissions (RDE) with portable emission measuring system (PEMS) in an appropriate road circuit became an obligatory element of new type approval of passenger cars since September 2017. In several projects the Laboratory for Exhaust Emissions Control (AFHB) of the Berne University of Applied Sciences (BFH) performed comparisons on
Czerwinski, Jan, Zimmerli, Yan, Hüssy, Andreas, Engelmann, Danilo, Bonsack, Peter, Remmele, Edgar, Huber, Georg   +6 more
openaire   +1 more source