Results 71 to 80 of about 6,678,922 (284)

Assessment of real driving emissions via portable emission measurement system [PDF]

IOP Conference Series: Materials Science and Engineering, 2017
The European Commission approved a so-called Real Driving Emission (RDE) test in response to the criticisms to the current driving cycle used at chassis dyno for homologation purpose (NEDC): it is considered outdated and misleading since air pollutants in real driving conditions are considerably higher than the certification thresholds.
A Clenci, V Sălan, R Niculescu, V Iorga-Simăn, C Zaharia   +4 more
openaire   +1 more source

Investigation on An Innovative Hydrocarbon Sensor for Real Drive Emissions

Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 2021
European law specifies limit values (and test methods) for pollutant emissions from light duty vehicles and heavy-duty engines including carbon monoxide (CO), hydrocarbons (HC), nitrogen oxide (NOx) and particulates, which are considered dangerous to human health.
null Muhammad Nor Azril Zulkafli, null Norazlianie Sazali, null Saiful Anwar Che Ghani, null Maurice Kettner   +3 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

ParcEMon: IoT Platform for Real-Time Parcel Level Last-Mile Delivery Greenhouse Gas Emissions Reporting and Management

Sensors, 2022
Transport is Australia’s third-largest source of greenhouse gases accounting for around 17% of emissions. In recent times, and particularly as a result of the global pandemic, the rapid growth within the e-commerce sector has contributed to last-mile ...
Ali Yavari, Hamid Bagha, Harindu Korala, Irfan Mirza, Hussein Dia, Paul Scifleet, Jason Sargent, Mahnaz Shafiei   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Energy management strategies for hybrid diesel vehicles by dynamic planning embedded in real-world driving emission model

Case Studies in Thermal Engineering
The optimization of energy management strategy for hybrid vehicles is often based on engine steady performance data and the standard driving cycle conditions in the laboratory.
Yingzhang Wang, Li Zhang, Yang Chen, Chaokai Li, Baocheng Du, Jinlin Han   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Constructing Emission-Intensive Driving Cycles for an Extended-Range Electric Vehicle via Dynamic Programming Guided by Real-World Trip Dynamics and Road Terrain

Applied Sciences
Reproducing severe emission driving scenarios on a chassis dynamometer enables the systematic calibration of real driving emissions (RDE) under laboratory conditions.
Yang Chen, Hualong Xu, Li Zhang, Qing Zhang, Chengzhi Jian   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source