Results 61 to 70 of about 226,928 (306)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Energy Management Strategies for Extended-Range Electric Vehicles with Real Driving Emission Constraints

Applied Sciences
Fuel economy has long been the core control objective in the energy management strategies of extended-range electric vehicles (EREVs), but little research has considered real driving emissions.
Hualong Xu, Yang Chen, Li Zhang, Guoliang Chen, Jinlin Han, Qing Zhang, Chaokai Li   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

ParcEMon: IoT Platform for Real-Time Parcel Level Last-Mile Delivery Greenhouse Gas Emissions Reporting and Management

Sensors, 2022
Transport is Australia’s third-largest source of greenhouse gases accounting for around 17% of emissions. In recent times, and particularly as a result of the global pandemic, the rapid growth within the e-commerce sector has contributed to last-mile ...
Ali Yavari, Hamid Bagha, Harindu Korala, Irfan Mirza, Hussein Dia, Paul Scifleet, Jason Sargent, Mahnaz Shafiei   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Real Driving Range in Electric Vehicles: Influence on Fuel Consumption and Carbon Emissions

World Electric Vehicle Journal, 2021
This paper is focused on the determination of real driving ranges for electric vehicles (EV’s) and how it influences fuel consumption and carbon emissions. A precise method to evaluate the driving range of an EV can establish the correct reduction in GEI
Carlos Armenta-Déu, Erwan Cattin
doaj   +1 more source

Building a Driving Simulator as an Electric Vehicle Hardware Development Tool [PDF]

, 2012
Driving simulators have been used to support the development of new vehicle systems for many years. The rise of electric vehicles (EVs) as a means of reducing carbon emissions has lead to the emergence of a number of new design ...
Knowles, Michael, Kok, Dirk, Morris, Adrian   +2 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Energy management strategies for hybrid diesel vehicles by dynamic planning embedded in real-world driving emission model

Case Studies in Thermal Engineering
The optimization of energy management strategy for hybrid vehicles is often based on engine steady performance data and the standard driving cycle conditions in the laboratory.
Yingzhang Wang, Li Zhang, Yang Chen, Chaokai Li, Baocheng Du, Jinlin Han   +5 more
doaj   +1 more source

A Distributed and Privacy-Aware Speed Advisory System for Optimising Conventional and Electric Vehicles Networks [PDF]

, 2015
One of the key ideas to make Intelligent Transportation Systems (ITS) work effectively is to deploy advanced communication and cooperative control technologies among the vehicles and road infrastructures.
Crisostomi, Emanuele, Gu, Yingqi, Liu, Mingming, Ordóñez-Hurtado, Rodrigo H., Shorten, Robert, Wirth, Fabian   +5 more
core   +3 more sources