Results 211 to 220 of about 3,428,091 (391)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The critical need for robust decision support in the era of precision cancer therapeutics. [PDF]

Explor Target Antitumor Ther
Markman M.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

External validation of the budget impact analysis of the drug fingolimode in the treatment of multiple sclerosis. [PDF]

Cost Eff Resour Alloc
Campello CRS, da Costa MGS, Pinto M.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Research on emission reduction investment strategies for low carbon technology enterprises. [PDF]

PLoS One
Li J, Yang T, Shi L.
europepmc   +1 more source

A REAL OPTIONS APPROACH TO INVESTMENT ANALYSIS OF AUTOMATIC MILKING SYSTEMS [PDF]

Automatic, or robotic, milking systems are beginning to be introduced to U.S. dairy farmers. This paper employs an ex ante approach to real options investment analysis of automatic milking systems.Livestock Production/Industries,
Engel, Phoebe D., Hyde, Jeffrey
core   +1 more source

Making real options analysis more accessible for climate change adaptation. An application to afforestation as a flood management measure in the Scottish Borders.

Journal of Environmental Management, 2019
Ruth Dittrich, A. Butler, T. Ball, A. Wreford, D. Moran   +4 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

General principles of application of the real options valuation in investment analysis

, 2015
U.Ya. Vytvytska
openalex   +1 more source