Results 201 to 210 of about 18,885,351 (305)

Different interpretations of inconclusive results of SARS-CoV-2 real-time RT PCR. [PDF]

Diagn Microbiol Infect Dis, 2023
La Jeon Y, Lee SG, Lee EH, Song S, Go UY, Chun GY.   +5 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Diagnostic utility of real-time RT-PCR for chikungunya virus detection in the acute phase of infection: a retrospective study. [PDF]

Ann Med
Sajith A, Iyengar V, Varamballi P, Mukhopadhyay C, Nittur S.   +4 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Correction: Morales et al. Modification and Validation of a Reference Real-Time RT-PCR Method for the Detection of a New African Horse Sickness Virus Variant. <i>Microorganisms</i> 2025, <i>13</i>, 2684. [PDF]

Microorganisms
Morales J, Ruano MJ, Tena-Tomás C, van Schalkwyk A, Loundras EA, Valero-Lorenzo M, López-Herranz A, Romito M, Batten C, Villalba R, Agüero M.   +10 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Development and Evaluation of a New Measles Detection Assay Using Real-Time RT-PCR. [PDF]

Int J Mol Sci
Chayeb VA, Dolgova AS, Popova MR, Zheleznova NV, Shirobokova SA, Shabalina AV, Sharova AA, Gladkikh AS, Antipova AY, Kirichenko AD, Ramsay ES, Dedkov VG.   +11 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

DIFFERENTIAL DIAGNOSIS OF RESPIRATORY VIRUSES BY USING REAL TIME RT-PCR METHODOLOGY

Revista do Instituto de Medicina Tropical de São Paulo, 2013
Renato de Souza Paulino, Margarete Aparecida Benega, Katia Correa de Oliveira Santos, Daniela Bernardes Borges da Silva, Juliana Cristina Pereira, Norio Augusto Sasaki, Patricia Evelin Silva, Suely Pires Curti, Maria Isabel Oliveira, Telma R.M.P. Carvalhanas, Teresa Peret, Dean Erdman, Terezinha Maria de Paiva   +12 more
doaj   +1 more source

Development of a Multiplex TaqMan Real-Time RT-PCR Assay for the Rapid Differential Detection of Classic, MLB-Clade and VA-Clade Human Astroviruses. [PDF]

J Microbiol Biotechnol
Zheng P, Wang J, Yu H, Luo Q, Gao H, Jin Z, Shi Y, Wang H, Li P, Tian F.   +9 more
europepmc   +1 more source