Results 141 to 150 of about 128,797 (311)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Ontic Structural Realism, Information, and Natural Necessity: Where Naturalism and Analytic Metaphysics Can Find Common Ground [PDF]
J. Ladyman (1998-2009), Ladyman and Ross (2007) refine J. Worral's (1998) structural realism (SR), by developing an ontic structural realism (OSR) which they argue is a consistently naturalistic means of characterizing the ontology of fundamental physics.
Kallfelz, William
core
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Thucydides: origins of realism?
, 2018 It is a well-established idea in mainstream International Relations theory that the ancient Greek historian Thucydides was a Realist, and the originator of some key Realist ideas.
Morley, NDG
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Kant's Transcendental Idealism and Contemporary Anti-Realism
, 2003 This paper compares Kant's transcendental idealism with three main groups of contemporary anti-realism, associated with Wittgenstein, Putnam, and Dummett, respectively.
Lucy Allais (16059272)
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Intro -- Essays on Linguistic Realism -- Editorial page -- Title page -- LCC data -- Table of contents -- Introduction to Essays on Linguistic Realism -- 1. Three kinds of linguistics -- 2. The chapters of the volume -- 3.
Behme, Christina., Neef, Martin.
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source