Results 121 to 130 of about 128,797 (311)

Predicting Perceived Realism in Virtual Reality Driving Simulations Using Participants’ Personality Traits, Heart Rate Changes, and Risk Preference

IEEE Access
Virtual reality (VR) has recently been adopted for driving simulations to enhance their realism and thus improve the validity of the simulation results. However, given that perceived realism is a subjective factor that varies by individual, understanding
Uijong Ju, Sanghyeon Kim
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

“New” Realism as a Problem of Method [PDF]

Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014
The development of the discussion on “Speculative Realism” and “Speculative Materialism” is very well documented. However, in order to better understand the overall project of this “New Realism” it is helpful to draw light to the genealogy and context in
Marko Bosnić
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Entity Realism

, 2018
This chapter discusses an approach known as entity realism or experimental realism, which was introduced in the early 1980s by Ian Hacking and Nancy Cartwright and seeks to defend some middle ground between traditional scientific realism and antirealism.
Egg, Matthias
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Realism

Realism is commonly understood in International Relations (IR) as a theory that focuses on the state and considers the international as a conflictual and competitive realm of self-help.
Felix Roesch (16999116)
core  

Epistemic Structural Realism and Poincare's Philosophy of Science [PDF]

, 2013
Recent discussions of structuralist approaches to scientific theories have stemmed primarily from Worrall's (1989), in which he defends a position (since characterized `epistemic structural realism') whose historical roots he attributes to Poincare.
Brading, Katherine, Crull, Elise
core  

Critical realism as a fractal philosophy [PDF]

There are two overarching questions that guide this paper: What are some potential issues with the criterion for judgemental rationality as developed by Bhaskar?
Isaksen, Karl Robert
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source