Results 121 to 130 of about 568,913 (306)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
“New” Realism as a Problem of Method [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014 The development of the discussion on “Speculative Realism” and “Speculative Materialism” is very well documented. However, in order to better understand the overall project of this “New Realism” it is helpful to draw light to the genealogy and context in
Marko Bosnić
doaj
Naive Realism for Unconscious Perceptions [PDF]
Unconscious perceptions (i.e., person-level perceptions that lack phenomenal character) have recently become a focal point in the debate for and against naive realism. In this paper I defend the naive realist side.
Beck, Ori
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Naïve realism and phenomenal similarity [PDF]
It has been claimed that naïve realism predicts phenomenological similarities where there are none and, thereby, mischaracterizes the phenomenal character of perceptual experience. If true, this undercuts a key motivation for the view.
Anaya, Alfonso, Clarke, Sam
core
Critical Realism and Ecological Economics: Counter-Intuitive Adversaries or Ostensible Soulmates? [PDF]
, 2016 The paper questions the compatibility of critical realism with ecological economics. In particular, it is argued that there is radical dissonance between ontological presuppositions of ecological economics and critical realist perspective. The dissonance
Likavčan, Lukáš
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Three Problems in Westphal's Transcendental Proof of Realism [PDF]
, 2010 The debate on how to interpret Kant's transcendental idealism has been prominent for several decades now. In his book Kant's Transcendental Proof of Realism Kenneth R.
Kannisto, Toni
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source