Results 101 to 110 of about 128,797 (311)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Structural Realism: Continuity and its Limits [PDF]
, 2009 Structural realists of nearly all stripes endorse the structural continuity claim. Roughly speaking, this is the claim that the structure of successful scientific theories survives theory change because it has latched on to the structure of the world. In
Votsis, Ioannis
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21: Inquiries into Art, History, and the VisualThe German artist Carl Grossberg produced pictures of machinery and architecture from the 1910s until his death in 1940. Precise, realist, yet often dreamlike, his pictures – associated with the Neue Sachlichkeit – are presented here as dynamic responses
Joe Bucciero
doaj +1 more source
MAGICAL REALISM-LIKE IN SHAKESPEARE'S A MIDSUMMER NIGHT'S DREAM
Jentera: Jurnal Kajian Sastra, 2018 This article uses concepts of magical realism by Wendy B. Faris to analyze Shakespeare's A Midsummer Night's Dream. We analyze elements of magical realism of the work in mapping discourses between the text and the real life.
Dio Catur Prasetyohadi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Modal Rationalism and Constructive Realism: Models and Their Modality [PDF]
, 2010 I present a case for a rapprochement between aspects of rationalism and scientific realism, by way of a general framework employing modal epistemology and elements of 2-dimensional semantics (2DS). My overall argument strategy is meta-inductive: The bulk
Kallfelz, William
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
KITCHER’S MODEST REALISM: THE RECONCEPTUALIZATION OF SCIENTIFIC OBJECTIVITY [PDF]
, 2010 In Science, Truth and Democracy, Kitcher moderates the strongest ontological realist thesis he defended in The Advancement of Science, with the aim of making compatible the correspondence theory of truth with conceptual relativity.
Dieguez, Antonio
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Scientific Realism and High-Energy Physics
, 2017 The article discusses the implications of high-energy physics for the scientific realism debate. After a brief introduction to high-energy physics, the anti-realist import of the erosion of intuition-based concepts in the context of high-energy physics ...
Dawid, Richard,, Richard Dawid
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