Results 91 to 100 of about 195,163 (307)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2018 This chapter discusses an approach known as entity realism or experimental realism, which was introduced in the early 1980s by Ian Hacking and Nancy Cartwright and seeks to defend some middle ground between traditional scientific realism and antirealism.
Egg, Matthias
core +1 more source
Scientific realism and the history of science [PDF]
, 2005 The paper considers the two main challenges to scientific realism, stemming from confirmation holism and the underdetermination thesis as well as from semantic holism and the incommensurability thesis. Against the first challenge, it is argued that there
Esfeld, Michael
core
Assessing the visual realism of deepfake videos: an IQA-based approach [PDF]
PeerJ Computer ScienceAs deepfake videos become increasingly realistic, the ability of detection models to generalize across manipulation techniques with varying degrees of visual realism has become critical.
Ahmet Demir +2 more
doaj +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Modal Rationalism and Constructive Realism: Models and Their Modality [PDF]
, 2010 I present a case for a rapprochement between aspects of rationalism and scientific realism, by way of a general framework employing modal epistemology and elements of 2-dimensional semantics (2DS). My overall argument strategy is meta-inductive: The bulk
Kallfelz, William
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Critical Realism in Economics and Open-Systems Ontology: A Critique [PDF]
This paper examines the treatment of ontology offered by Critical Realism. Three main criticisms are made of the Critical Realist treatment of open systems.
Andrew Mearman
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Why the Ultimate Argument for Scientific Realism Ultimately Fails [PDF]
, 2011 In this paper, I argue that the ultimate argument for Scientific Realism, also known as the No-Miracles Argument (NMA), ultimately fails as an abductive defence of Epistemic Scientific Realism (ESR), where (ESR) is the thesis that successful theories of ...
Mizrahi, Moti
core
Scientific Realism and High-Energy Physics
, 2017 The article discusses the implications of high-energy physics for the scientific realism debate. After a brief introduction to high-energy physics, the anti-realist import of the erosion of intuition-based concepts in the context of high-energy physics ...
Dawid, Richard,, Richard Dawid
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