Results 81 to 90 of about 568,913 (306)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Religious Ethics and Moral Realism [PDF]
اخلاق وحیانی, 2015 The purpose of this paper is to explore the relations between various forms of moral realism and some views about religious ethics, particularly, religious ethics in the Islamic tradition, although much of what is said will apply to ethical views in ...
Hajj Muhammad Legenhausen
doaj
Can the empirical sciences contribute to the moral realism/anti-realism debate? [PDF]
, 2018 An increasing number of moral realists and anti-realists have recently attempted to support their views by appeal to science. Arguments of this kind are typically criticized on the object-level.
Pölzler, Thomas
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Liquid Realism: Hauntology, Lack, and Mourning as Method
Open PhilosophyThis article proposes liquid realism as a term to describe a critical stance that constitutes a metamodern methodology. Drawing on Zygmunt Bauman’s liquid modernity, Mark Fisher’s hauntology, and Jacques Lacan’s conception of the real as structural lack,
Edgar Robert
doaj +1 more source
Relativity, Anomalies and Objectivity Loophole in Recent Tests of Local Realism
, 2017 Local realism is in conflict with special quantum Bell-type models. Recently, several experiments have demonstrated violation of local realism if we trust their setup assuming special relativity valid.
Bednorz, Adam
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
In Defense of Realism and Selectivism from Lyons’s Objections [PDF]
, 2019 Lyons (2016, 2017, 2018) formulates Laudan’s (1981) historical objection to scientific realism as a modus tollens. I present a better formulation of Laudan’s objection, and then argue that Lyons’s formulation is supererogatory.
Park, Seungbae
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source