Results 81 to 90 of about 188,752 (308)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A critique of continental anti-realism
, 2023 Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Communication, Arts and Critical Enquiry, Faculty of Humanities and Social Sciences, La Trobe University, Bundoora.A ...
Sebold, Richard (14361555)
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Did Perrin's experiments convert Poincaré to Scientific Realism? [PDF]
, 2013 In this paper I argue that Poincaré’s acceptance of the atom does not indicate a shift from instrumentalism to scientific realism. I examine the implications of Poincaré’s acceptance of the existence of the atom for our current understanding of his ...
Ivanova, Milena
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Scientific Realism, the Galilean Strategy, and Representation [PDF]
, 2009 This paper critically reviews Philip Kitcher’s most recent epistemology of science, real realism. I argue that this view is unstable under different understandings of the term “representation”, and that the arguments offered for the position are either ...
Suárez, Mauricio
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Nonconceptual Content, Causal Theory, and Realism
The Baltic International Yearbook of Cognition, Logic and Communication, 2014 In this paper the connections between the nonconceptual content of perceptual states and realism are considered. In particular, I investigate the argument for realism that uses the notion of nonconceptual content, specifically the version proposed by ...
Błażej Skrzypulec
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Political realism, Freud, and human nature in international relations [PDF]
, 2009 Political realism has enjoyed a renaissance in International Relations (IR). Recent studies have provided insightful accounts of its timeless virtues and philosophical depth.
Schütt, Robert, Schuett, R
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21: Inquiries into Art, History, and the VisualThe German artist Carl Grossberg produced pictures of machinery and architecture from the 1910s until his death in 1940. Precise, realist, yet often dreamlike, his pictures – associated with the Neue Sachlichkeit – are presented here as dynamic responses
Joe Bucciero
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