Results 111 to 120 of about 195,163 (307)

Is Moore’s Moral Objectivist Argument Sufficient Against Moral Relativism?

open access: yesMarifetname
This study aims to expose certain weaknesses in Moore’s moral objectivist argument against moral relativism and subjectivism. It suggests that a moral objectivist argument has to explain moral diversity against moral relativism ...
Burhan Başarslan
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

MAGICAL REALISM-LIKE IN SHAKESPEARE'S A MIDSUMMER NIGHT'S DREAM

open access: yesJentera: Jurnal Kajian Sastra, 2018
This article uses concepts of magical realism by Wendy B. Faris to analyze Shakespeare's A Midsummer Night's Dream. We analyze elements of magical realism of the work in mapping discourses between the text and the real life.
Dio Catur Prasetyohadi   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

ROMAN INGARDEN: OD REALIZMU FENOMENOLOGICZNEGO DO MORALNEGO [PDF]

open access: yesThe Polish Journal of Aesthetics, 2003
Man is the cornerstone of Ingarden's philosophy. His position in his essay “On Responsibility” marks confirmation of his permanent interest in man and the final departure from the idealism-realism problematic.
Edward M. Swiderski
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

A critique of continental anti-realism

open access: yes, 2013
Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Communication, Arts and Critical Enquiry, Faculty of Humanities and Social Sciences, La Trobe University, Bundoora.A ...
Sebold, Richard (14361555)   +1 more
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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