Results 111 to 120 of about 188,752 (308)

Inconsistency and Scientific Realism [PDF]

open access: yes, 2013
I erect a framework within the semantic view of theories for explaining the empirical success of internally inconsistent models and theories, with scientific realism in mind.
Saatsi, Juha
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modal Rationalism and Constructive Realism: Models and Their Modality [PDF]

open access: yes, 2010
I present a case for a rapprochement between aspects of rationalism and scientific realism, by way of a general framework employing modal epistemology and elements of 2-dimensional semantics (2DS). My overall argument strategy is meta-inductive: The bulk
Kallfelz, William
core  

Critical Realism, Gender and Feminism : Exchanges, Challenges, Synergies

open access: yes, 2016
Editorial to the special issue of JCR on Critical Realism, Gender and ...
Gunnarsson, Lena,   +2 more
core   +1 more source

Algumas notas sobre “realismo” e “ultrarealismo” em Sartre

open access: yesDoisPontos, 2006
This paper intends to research the possibility of thinking the several elements of Sartre's works according to one axe named "realism". It is important to explain what "realism" means here. Not intending find out a definition of "realism". Here "realism"
Alexandre de Oliveira Torres Carrasco
doaj  

“New” Realism as a Problem of Method [PDF]

open access: yesMeta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014
The development of the discussion on “Speculative Realism” and “Speculative Materialism” is very well documented. However, in order to better understand the overall project of this “New Realism” it is helpful to draw light to the genealogy and context in
Marko Bosnić
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Predicting Perceived Realism in Virtual Reality Driving Simulations Using Participants’ Personality Traits, Heart Rate Changes, and Risk Preference

open access: yesIEEE Access
Virtual reality (VR) has recently been adopted for driving simulations to enhance their realism and thus improve the validity of the simulation results. However, given that perceived realism is a subjective factor that varies by individual, understanding
Uijong Ju, Sanghyeon Kim
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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