Results 101 to 110 of about 4,584,624 (305)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

The impact of intraoperative optical coherence tomography on cognitive load in virtual reality vitreoretinal surgery training

open access: yesScientific Reports
Ophthalmic surgeries consist of highly demanding microsurgical tasks that require surgeons to sustain mental focus and extreme manual dexterity for extended periods.
Laura Schütz   +4 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Exploring Oculus Rift: A Historical Analysis of the ‘Virtual Reality’ Paradigm [PDF]

open access: yes, 2017
This paper will first provide background information about Virtual Reality in order to better analyze its development throughout history and into the future.
Gammage, Chastin
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Learnable Wireless Digital Twins: Reconstructing Electromagnetic Field With Neural Representations

open access: yesIEEE Open Journal of the Communications Society
Wireless digital twins, which approximate the communication environment and signal propagation, find many applications in system design and operation, and are envisioned as key enablers for future wireless systems.
Shuaifeng Jiang   +5 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Multiple-Echo Suppression Modeling and Experimental Verification for Acoustic Transmission along Periodic Drillstring Using Dual Receivers

open access: yesShock and Vibration, 2014
In the oil industry, the accompanied reverberation is a major constraint in the transmission rate and distance because the drillstring is a heterogeneous assembly.
Li Cheng   +3 more
doaj   +1 more source

Substance, Reality, and Distinctness [PDF]

open access: yes, 2008
Descartes claims that God is a substance and that mind and body are two different and separable substances. This paper provides some background that renders these claims intelligible.
Hennig, Boris
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

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