Results 41 to 50 of about 229,890 (199)
Rapidity of Genomic Adaptations to Prasinovirus Infection in a Marine Microalga
Viruses, 2018 Prasinoviruses are large dsDNA viruses commonly found in aquatic systems worldwide, where they can infect and lyse unicellular prasinophyte algae such as Ostreococcus.
Sheree Yau +5 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cationic cobalt-catalyzed [1,3]-rearrangement of N-alkoxycarbonyloxyanilines
Beilstein Journal of Organic Chemistry, 2018 A cationic cobalt catalyst efficiently promoted the reaction of N-alkoxycarbonyloxyanilines at 30 °C, affording the corresponding ortho-aminophenols in good to high yields.
Itaru Nakamura +3 more
doaj +1 more source
Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2-carboxylate
Molbank, 2017 This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine
Marcus Baumann, Ian R. Baxendale
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
On an analog of the M.G. Krein theorem for measurable operators
Учёные записки Казанского университета: Серия Физико-математические науки, 2018 Let M be a von Neumann algebra of operators on a Hilbert space H and τ be a faithful normal semifinite trace on M. Let μt(T), t > 0, be a rearrangement of a τ-measurable operator T. Let us consider a τ-measurable operator A, such that μt(A) > 0 for all t
A.M. Bikchentaev
doaj
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Rearrangements of dicarba-nido-undecaborates
Тонкие химические технологии, 2011 The thermal and chemically initiated thermal rearrangements of dicarba-nido-undecaborates was explored by computational chemistry. It was shown that the kinetic stability of dianions of these compounds is reduced in the series 2,9 > 7,8 > 1,7 > ...
S. P. Knyazev, A. Yu. Kostiykovitch
doaj
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2013 Oxidative cyclization of 6-chloro-4-pyrimidinylhydrazones 4 with iodobenzene diacetate (IBD) in dichloromethane gives rise to [1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a–o.
Caifei Tang, Zhiming Li, Quanrui Wang
doaj +1 more source