Results 41 to 50 of about 545,522 (315)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille +9 more
wiley +1 more source
Cemeteries and Urban Planning in Vienna
Urban Science(1) Background: As social infrastructures, cemeteries have always played a central role in various human cultures. The changing function of cemeteries and the recognition of their potential as green spaces have resulted in the fact that cemeteries are a ...
Raimund Wiesinger, Tatjana Fischer
doaj +1 more source
Glycolytic regulation of cell rearrangement in angiogenesis
Nature Communications, 2016 During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel sprouting by regulating cytoskeleton ...
B. Cruys +15 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
Mitigating the levee effect – Spatial planning approaches to address residual risk
Progress in Disaster ScienceThe levee effect poses a challenge for flood risk management. While there is research on the consequences of the levee effect in general, a detailed understanding of policies addressing residual risk is lacking.
Lena Junger, Walter Seher
doaj +1 more source
The Lancet Oncology, 2011 Summary Background ALK gene rearrangement defines a new molecular subtype of non-small-cell lung cancer (NSCLC). In a recent phase 1 clinical trial, the ALK tyrosine-kinase inhibitor (TKI) crizotinib showed marked antitumour activity in patients with ...
A. Shaw +22 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier +10 more
wiley +1 more source
Rearrangements of organic peroxides and related processes
Beilstein Journal of Organic Chemistry, 2016 This review is the first to collate and summarize main data on named and unnamed rearrangement reactions of peroxides. It should be noted, that in the chemistry of peroxides two types of processes are considered under the term rearrangements.
Ivan A. Yaremenko +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen +21 more
wiley +1 more source
Targeting ALK Rearrangements in NSCLC: Current State of the Art
Frontiers in Oncology, 2022 Anaplastic lymphoma kinase (ALK) alterations in non-small cell lung cancer (NSCLC) can be effectively treated with a variety of ALK-targeted drugs. After the approval of the first-generation ALK inhibitor crizotinib which achieved better results in ...
Ling Peng +6 more
doaj +1 more source