Results 21 to 30 of about 13,195 (161)

Influenza A virus reassortment in mammals gives rise to genetically distinct within-host subpopulations

Nature Communications, 2022
Virus reassortment drives genetic diversity and evolution and is governed by intra-host dynamics that are less well understood. Here, the authors characterise the within-host dynamics of influenza A virus reassortment in swine, ferrets and guinea pigs ...
Ketaki Ganti, Anish Bagga, Silvia Carnaccini, Lucas M. Ferreri, Ginger Geiger, C. Joaquin Caceres, Brittany Seibert, Yonghai Li, Liping Wang, Taeyong Kwon, Yuhao Li, Igor Morozov, Wenjun Ma, Juergen A. Richt, Daniel R. Perez, Katia Koelle, Anice C. Lowen   +16 more
doaj   +1 more source

Intrasubtype reassortments cause adaptive amino acid replacements in H3N2 influenza genes. [PDF]

PLoS Genetics, 2014
Reassortments and point mutations are two major contributors to diversity of Influenza A virus; however, the link between these two processes is unclear.
Alexey D Neverov, Ksenia V Lezhnina, Alexey S Kondrashov, Georgii A Bazykin   +3 more
doaj   +1 more source

Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014. [PDF]

PLoS ONE, 2017
Reassortment of genetic segments between and within influenza B lineages (Victoria and Yamagata) has been shown to generate novel reassortants with unique genetic characteristics.
Xiang Yong Oong, Kim Tien Ng, Joon Ling Tan, Kok Gan Chan, Adeeba Kamarulzaman, Yoke Fun Chan, I-Ching Sam, Kok Keng Tee   +7 more
doaj   +1 more source

Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed by Defective Interfering Particles.

PLoS Pathogens, 2015
A high particle to infectivity ratio is a feature common to many RNA viruses, with ~90-99% of particles unable to initiate a productive infection under low multiplicity conditions. A recent publication by Brooke et al.
Judith M Fonville, Nicolle Marshall, Hui Tao, John Steel, Anice C Lowen   +4 more
doaj   +1 more source

TreeKnit: Inferring ancestral reassortment graphs of influenza viruses.

PLoS Computational Biology, 2022
When two influenza viruses co-infect the same cell, they can exchange genome segments in a process known as reassortment. Reassortment is an important source of genetic diversity and is known to have been involved in the emergence of most pandemic ...
Pierre Barrat-Charlaix, Timothy G Vaughan, Richard A Neher   +2 more
doaj   +1 more source

In Vitro Reassortment between Endemic Bluetongue Viruses Features Global Shifts in Segment Frequencies and Preferred Segment Combinations

Microorganisms, 2021
Bluetongue virus (BTV) is an arthropod-borne pathogen that is associated with sometimes severe disease in both domestic and wild ruminants. Predominantly transmitted by Culicoides spp.
Jennifer Kopanke, Justin Lee, Mark Stenglein, Christie Mayo   +3 more
doaj   +1 more source

Predicting Hotspots for Influenza Virus Reassortment

Emerging Infectious Diseases, 2013
The 1957 and 1968 influenza pandemics, each of which killed ≈1 million persons, arose through reassortment events. Influenza virus in humans and domestic animals could reassort and cause another pandemic.
Trevon L. Fuller, Marius Gilbert, Vincent Martin, Julien Cappelle, Parviez Hosseini, Kevin Y. Njabo, Soad Abdel Aziz, Xiangming Xiao, Peter Daszak, Thomas B. Smith   +9 more
doaj   +1 more source

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens. [PDF]

PLoS Pathogens, 2006
Many bacterial pathogens employ a type III secretion system to deliver type III secreted effectors (T3SEs) into host cells, where they interact directly with host substrates to modulate defense pathways and promote disease.
John Stavrinides, Wenbo Ma, David S Guttman   +2 more
doaj   +1 more source

Safety and Efficacy of Plant‐Produced Trivalent Virus‐Like Particle Vaccine Candidate Against Bluetongue Disease

Plant Biotechnology Journal, EarlyView.
ABSTRACT Bluetongue (BT) is a non‐contagious, insect‐transmitted disease of wild and domestic ruminants caused by bluetongue virus (BTV). Effective control of BT disease relies on vaccination against prevalent or seasonal serotypes using live attenuated or inactivated vaccines.
Tendai A. M. Mlingo, Martha M. O'Kennedy, Matome Matsiela, Ntombikayise Nkomo, Peter Coetzee, Thapelo Rametse, Paidamwoyo Mutowembwa, Livio Heath, Nobalanda Mokoena   +8 more
wiley   +1 more source

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source