Results 41 to 50 of about 2,483 (129)

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model [PDF]

, 2015
The corticotropin-releasing factor (CRF)-producing neurons of the amygdala have been implicated in behavioral and physiological responses associated with fear, anxiety, stress, food intake and reward.
Cabral, Agustina, De Francesco, Pablo, Osborne-Lawrence, S., Perelló, Mario, Raingo, Jesica, Reynaldo, Mirta Beatriz, Sakata, I., Valdivia Torres, Lesly Spring, Zigman, J.M.   +8 more
core   +2 more sources

Megalocytivirus: A Review of Epidemiology, Pathogenicity, Immune Evasion, and Prevention Strategies

Reviews in Aquaculture, Volume 17, Issue 3, June 2025.
ABSTRACT Megalocytivirus, a large double‐stranded DNA virus belonging to the Iridoviridae family, has infected over 100 species of fish, leading to significant economic losses in the aquaculture, food, and ornamental fish industries. These viruses exhibit icosahedral symmetry and have diameters ranging from 120 to 200 nm.
Changjun Guo, Jian He, Xiaopeng Xu, Shaoping Weng, Jianguo He   +4 more
wiley   +1 more source

Genetically Engineered Phages: a Review of Advances over the Last Decade [PDF]

, 2016
Summary: Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized.
Alberts B, Bruynoghe R, CDC, Chan LY, d'Herelle F, d'Hérelle F, d'Hérelle F, Dever LA, Górski A, Lodish H, Makarova KS, Miyake H, Murphy MP, Rose T, Summers WC, Vaara M, Weber-Dabrowska B, WHO   +17 more
core   +1 more source

Cerebral vascular malformations: pathogenesis and therapy

MedComm, Volume 5, Issue 12, December 2024.
CVMs management based on imaging genomics and liquid biopsy. In the future, somatic or de novo germline mutation information could be used to direct neurosurgical and medical management of CVMs. Somatic or germline variants can be acquired from imaging genomics or liquid biopsies preoperatively.
Qiheng He, Ran Huo, Yingfan Sun, Zhiyao Zheng, Hongyuan Xu, Shaozhi Zhao, Yang Ni, Qifeng Yu, Yuming Jiao, Wenqian Zhang, Jizong Zhao, Yong Cao   +11 more
wiley   +1 more source

Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing

Small Science, Volume 4, Issue 10, October 2024.
This review examines the potential of clustered regularly interspaced short palindromic repeat (CRISPR) technology in cellular genetics, focusing on challenges like low delivery efficiency and off‐target effects. It discusses innovative carriers—viral, lipid‐based, polymeric particles, and exosomes—that improve stability, reduce side effects, and ...
Neda Rostami, Mohammad Mahmoudi Gomari, Edris Choupani, Shadi Abkhiz, Mahmood Fadaie, Seyed Sadegh Eslami, Zahra Mahmoudi, Yapei Zhang, Madhu Puri, Fatemeh Nafe Monfared, Elena Demireva, Vladimir N. Uversky, Bryan Ronain Smith, Sidi A. Bencherif   +13 more
wiley   +1 more source

Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin‐deficient muscle

The Journal of Physiology, Volume 602, Issue 20, Page 5229-5245, 15 October 2024.
Abstract figure legend Mavacamten, a myosin‐centred small molecule, directly enhances myosin ATP‐conserving biochemical state in muscle fibres from patients with nemaline myopathy (or mice lacking nebulin). However, in vivo treatment with Mavacamten for 4 weeks (in mice lacking nebulin) does not have significant effects on the muscle fibre energetic ...
Jenni Laitila, Robert A. E. Seaborne, Natasha Ranu, Justin S. Kolb, Carina Wallgren‐Pettersson, Nanna Witting, John Vissing, Juan Jesus Vilchez, Edmar Zanoteli, Johanna Palmio, Sanna Huovinen, Henk Granzier, Julien Ochala   +12 more
wiley   +1 more source

Staphylococcus aureus SOS response: Activation, impact, and drug targets

mLife, Volume 3, Issue 3, Page 343-366, September 2024.
Abstract Staphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and small colony variants.
Kaiying Cheng, Yukang Sun, Huan Yu, Yingxuan Hu, Yini He, Yuanyuan Shen   +5 more
wiley   +1 more source

Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na+ restriction

The Journal of Physiology, Volume 602, Issue 17, Page 4309-4326, 1 September 2024.
Abstract figure legend Mice lacking a key furin cleavage site in ENaC's α subunit were generated to assess the importance of α subunit proteolysis in vivo. When fed a control salt diet, there were no major phenotypic effects. However, when fed a Na+‐deficient diet, male furin site mutant mice showed impaired ENaC activation (channel open probability ...
Andrew J. Nickerson, Shaohu Sheng, Natalie A. Cox, Kennedy G. Szekely, Allison L. Marciszyn, Tracey Lam, Jingxin Chen, Sebastien Gingras, Ossama B. Kashlan, Annet Kirabo, Rebecca P. Hughey, Evan C. Ray, Thomas R. Kleyman   +12 more
wiley   +1 more source

Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering [PDF]

, 2016
Precise genome engineering is instrumental for biomedical research and holds great promise for future therapeutic applications. Site-specific recombinases (SSRs) are valuable tools for genome engineering due to their exceptional ability to mediate ...
Buchholz, Frank, Karimova, Madina, Karpinski, Janet, Pisabarro, M. Teresa, Splith, Victoria   +4 more
core   +1 more source

A change of view: Homologous recombination at single-molecule resolution [PDF]

, 2018
Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer.
de Tullio, Luisina, Greene, Eric C., Kaniecki, Kyle   +2 more
core   +1 more source