Results 31 to 40 of about 2,483 (129)

Efficient recombination between diverged sequences: the role of λ Red protein [PDF]

, 2010
Bakteriofagi su bakterijski virusi koji nastanjuju i najmanje kutke naše planete. Svrstavanje ovih organizama u skupine zadavalo je muke, a zadaje i danas mnogim znanstvenicima i istraživačima.
Rožić, Sara
core   +2 more sources

Disruption of the temporally regulated cloaca endodermal B-catenin signaling causes anorectal malformations [PDF]

, 2014
published_or_final_versio
Akita, K, Harada, M, Haraguchi, R, Inoue, C, Lui, VCH, Matsumaru, D, Matsushita, S, Miyagawa, S, Nakagata, N, Nakahara, C, Ng, CL, Suzuki, K, Tanaka, K, Yamada, G   +13 more
core   +2 more sources

Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Cerebral cavernous malformations (CCMs) are vascular lesions in the brain caused by inherited genetic mutations in the CCM1/2/3 genes that disrupt normal blood vessel function. This work demonstrates that these mutations lead to endothelial dysfunction, inflammation, and iron accumulation, which can be detected by magnetic resonance imaging (MRI) and ...
Fabrícia Lima Fontes‐Dantas, Gustavo da Fontoura Galvão, Alexandre Martins Cunha, Pedro de Sena Murteira Pinheiro, Verônica Morandi, Jorge Marcondes de Souza   +5 more
wiley   +1 more source

The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. [PDF]

, 2019
In eukaryotic meiosis, generation of haploid gametes depends on the formation of inter-homolog crossovers, which enable the pairing, physical linkage, and eventual segregation of homologs in the meiosis I division.
Arora, Kanika, Corbett, Kevin D
core  

Germinal center formation is resilient to CD69 deletion on T follicular helper cells

Immunology &Cell Biology, Volume 103, Issue 9, Page 844-856, October 2025.
CD69 is upregulated on human and mouse CD4+ T follicular helper (TFH) cells within the germinal center. In this article, we use an Il21‐cre mouse strain to ablate floxed Cd69 genes from TFH cells and a proportion of their precursors. We find that when TFH cells lack CD69, the germinal center response remains intact, supporting B‐cell affinity ...
Stephane M Guillaume, Helena A Carslaw, Silvia Innocentin, Louise M C Webb, Adrian Liston, William S Foster, Michelle A Linterman   +6 more
wiley   +1 more source

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu, Yajun Hou, Yuhang Cheng, Ziyun Li, Jiawei Zeng, Li Li, Jinyong Luo, Bo Shen   +7 more
wiley   +1 more source

Emerging Species and Genome Editing Tools: Future Prospects in Cyanobacterial Synthetic Biology [PDF]

, 2019
Recent advances in synthetic biology and an emerging algal biotechnology market have spurred a prolific increase in the availability of molecular tools for cyanobacterial research.
Gale, Grant A. R., Lea-Smith, David, McCormick, Alistair J., Mills, Lauren, Schiavon, Alejandra A., Wang, Baojun   +5 more
core   +2 more sources

A high security double lock and key mechanism in HUH relaxases controls oriT-processing for plasmid conjugation [PDF]

, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.Relaxases act as DNA selection sieves in conjugative plasmid transfer. Most plasmid relaxases belong to the HUH endonuclease family. TrwC, the relaxase
Carballeira, José Daniel, Cruz, Fernando de la, González-Pérez, Blanca, Moncalián, Gabriel   +3 more
core   +1 more source

Incomplete meiotic sex chromosome inactivation in the domestic dog [PDF]

, 2015
Background: In mammalian meiotic prophase, homologous chromosome recognition is aided by formation and repair of programmed DNA double-strand breaks (DSBs). Subsequently, stable associations form through homologous chromosome synapsis.
Baarends, W.M. (Willy), Cappellen, W.A. (Gert) van, Federici, F. (Federica), Grootegoed, J.A. (Anton), Heijden, G.W. (Godfried) van der, Hoogerbrugge, J.W. (Jos), IJcken, W.F.J. (Wilfred) van, Laven, J.S.E. (Joop), Mulugeta, E. (Eskeatnaf), Schoenmakers, S. (Sam), Slotman, J.A. (Johan A.), Wassenaar, E. (Evelyne)   +11 more
core   +4 more sources

Evolutionary Trajectories of Methionine Metabolism in Mycobacterium and Its Application to Engineer a Vitamin B12 Whole‐Cell Ribosensor

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
Molecular and functional experiments highlight the relevance of species‐specific polymorphisms in a B12 riboswitch of the Mycobacterium genus. This information provided proof‐of‐concept to engineer a whole‐cell biosensor capable of detecting vitamin B12. ABSTRACT Vitamin B12 metabolism differs among members of the Mycobacterium genus.
Elena Campos‐Pardos, Laura Sanz‐Asensio, Sandra Pérez‐Jiménez, Inmaculada Yruela, Bruno Contreras‐Moreira, Alejandro Toledo‐Arana, Jesús Gonzalo‐Asensio   +6 more
wiley   +1 more source