Results 11 to 20 of about 1,686 (92)

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients. [PDF]

J Clin Lab Anal
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Mutitanon S, Chaichanawongsaroj N.
europepmc   +2 more sources

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Advances in Double-Stranded DNA Targeting Technologies. [PDF]

Exploration (Beijing)
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Shen Z, Liu Y, Hao Y, Bo Y, Dai X, Wang S, Xia T, Su X, Liu H.   +8 more
europepmc   +2 more sources

Evolution of programmable zinc finger-recombinases with activity in human cells

, 2007
Site-specific recombinases are important tools for genomic engineering in many living systems. Applications of recombinases are, however, constrained by the DNA targeting endemic of the recombinase used. A tremendous range of recombinase applications can
Smith, Justin D., Gordley, Russll M., Gräslund, Torbjörn,, Barbas, Carlos F., III   +3 more
core   +1 more source

Association between the presence of phage recombination functions and the abundance of Chi sites.

, 2013
(A) Number of lambdoid phages encoding RecBCD inhibitors (Inh+/Inh−) and recombinases (Rec+/Rec−). (B) Distribution of the number of Chi sites observed/expected (O/E) ratios among lambdoid phages.
Louis-Marie Bobay (463384), Eduardo P. C. Rocha (7388), Marie Touchon (118515)   +2 more
core   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer, José E. Martínez, Luis Díaz‐Gómez, Miriam Sartages, Eva M. Esquinas‐Román, Cristina Riobello, David Martínez‐Delgado, Diego González‐Pérez, Aurora Gómez‐Durán, Miguel Fidalgo, Marta Varela‐Rey, Celia M. Pombo, Juan Zalvide   +12 more
wiley   +1 more source

Biochemical analysis of bacteriophage Orf family recombinases [PDF]

, 2012
Bacterial pathogen evolution is an important field of study in light of the emergence of new diseases and drug resistant strains. Genomic rearrangements facilitated by temperate bacteriophages provide a major route for bacteria to acquire new pathogenic ...
WALLACE, IAIN,DAVID
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Aplicación del sistema de recombinación específica de secuencia β-six al estudio de la regulación de la expresión génica en células eucariotas y modelos animales [PDF]

, 2016
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología II, leída el 26-01-2016Las recombinasas específicas de secuencia son herramientas muy valiosas en la generación de modificaciones génicas ...
Servert del Río, Pilar
core   +1 more source