Results 21 to 30 of about 2,483 (129)

The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis [PDF]

, 2016
Meiotic recombination is essential for the repair of programmed double strand breaks (DSBs) to generate crossovers (COs) during meiosis. The efficient processing of meiotic recombination intermediates not only needs various resolvases but also requires ...
A Adamo, A Agostinho, A Alpi, A Copsey, A De Muyt, A Kegel, A Losada, AE Franklin, AF Severson, AJ MacQueen, AM Rose, Ana Agostinho, Anton Gartner, B Meier, B Rockmill, BB Lemmens, BB Lemmens, Bettina Meier, Bin Wang, C Buhler, C Rinaldo, C Wicky, CF Cheok, CJ Tsai, CR Wagner, D Zickler, DE Verver, DE Verver, DG Mets, DL Croteau, EA Andrews, EP Mimitou, F Baudat, F Couteau, F Onoda, G Chung, G De Piccoli, GA Cromie, H Kaur, HL Klein, I Lilienthal, J Matos, J Matos, J Torres-Rosell, J. Julian Blow, Jeff Sekelsky, JH Stear, JM Murray, JS Bickel, K Jeppsson, K Nabeshima, K Zakharyevich, KA Manthei, KJ Hillers, L Timmons, LM Gallego-Paez, M Jagut, M McVey, M Pradillo, M Schvarzstein, M Shrivastav, M Terasawa, M Xaver, MC Zetka, MC Zetka, ME Serrentino, MM Grabowski, MR Lieber, MS Huen, MV Rockman, MW Davis, N Bhalla, N Cobbe, N Humphryes, N Phadnis, NJ O'Neil, PB Moens, PB Moens, PM Meneely, PR Potts, R Gomez, R Scully, R Yokoo, RC Chan, Remi Sonneville, S Keeney, S Rosu, S Smolikov, S Wehrkamp-Richter, S Wolters, SC Ip, SD Oh, SP Bellendir, T Goldfarb, T Hirano, TJ Broering, TT Saito, TT Saito, X Xu, Y Fujioka, Ye Hong   +100 more
core   +11 more sources

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Site-directed gene integration in transgenic zebrafish mediated by cre recombinase using a combination of mutant Lox sites [PDF]

, 2007
With current gene-transfer techniques in fish, insertion of DNA into the genome occurs randomly and in many instances at multiple sites. Associated position effects, copy number differences, and multiple gene interactions make gene expression experiments
Liu, Wei-Yi, Qin, Yao, Wang, Ya-Ping, Wang, Yun, Zhu, Zuo-Yan, Zhu, ZY, Wuhan Univ, Chinese Acad Sci, Grad Sch, Inst Hydrobiol,State Key Lab Freshwater Ecol & Bi, Wuhan 430072, Peoples R China   +5 more
core   +1 more source

Staphylococcal cassette chromosome mec containing a novel mec gene complex, B4 [PDF]

, 2021
OBJECTIVES: To describe a new subclass of mec class B complex identified in Staphylococcus epidermidis. METHODS: Four S. epidermidis isolates obtained from bloodstream infections in patients at University Medical Center Groningen (UMCG) were analysed by ...
Akkerboom, Viktoria, Bathoorn, Erik, Becker, Karsten, Durfee, Tim, Friedrich, Alexander W., Miskoski, Madalina, Sabat, Artur J.   +6 more
core   +1 more source

Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage [PDF]

, 2009
International audienceBackgroundStaphylococcus aureus is a major human pathogen responsible for a variety of nosocomial and community-acquired infections. Recent reports show that the prevalence of Methicillin-Resistant S.
David Hernandez, Didier Raoult, Emmanuelle Bosdure, Fadi Bittar, Ghislain Fournous, Herve Richet, Jacques Sarles, Jacques Schrenzel, Jean-Christophe Dubus, Jean-Marc Rolain, Martine Reynaud-Gaubert, Nathalie Stremler, Patrice Francois, Stephanie Boniface, Yves Mattenberger   +14 more
core   +5 more sources

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Molecular characterisation of O1 strains carrying an SXT/R391-like element from cholera outbreaks in Kenya: 1994-2007 [PDF]

, 2009
Background Over the last decade, cholera outbreaks in parts of Kenya have become common. Although a number of recent studies describe the epidemiology of cholera in Kenya, there is paucity of information concerning the diversity and occurrence of mobile ...
Butaye Patrick, Goddeeris Bruno M, Kariuki Samuel M, Kiiru John N, Saidi Suleiman M, Wamae Njeri C   +5 more
core   +5 more sources

Meiosis genes in and the role of parthenogenesis in genome evolution [PDF]

, 2009
Background Thousands of parthenogenetic animal species have been described and cytogenetic manifestations of this reproductive mode are well known. However, little is understood about the molecular determinants of parthenogenesis.
Andrew M Schurko, John M Logsdon, Brian D Eads, GN Stone, M Lynch, J Mallet, M Morgan-Richards, MF Dybdahl, C Wallace, PM Ferree, MG Riparbelli, E Suomalainen, TA Gorr, N Tatarazako, PD Hebert, F Zaffagnini, H Lumer, F Zaffagnini, AR Omilian, JK Colbourne, S Paland, M Lynch, PE Cohen, K Nasmyth, JL Gerton, S Hauf, M Petronczki, Y Watanabe, J Brennecke, AA Aravin, C Klattenhoff, T Kishimoto, AL Marston, JZ Morris, M Fu, Y Geng, S Ortega, M Malumbres, M Kasten, O Cohen-Fix, K Nasmyth, V Guacci, SP Bell, SL Forsburg, D Maiorano, HL Blanton, M Lutzmann, JW Barnes, AL Gotter, RC Chan, AL Gotter, JA Cobb, L Wu, RM Brosh Jr, ID Hickson, JL Plank, B Rockmill, PB Moens, DN Cox, K Nonomura, MA Ramesh, S Gruber, TS Kitajima, SE Thomas, L Strom, E Unal, I Sumara, A Losada, VL Katis, TS Kitajima, DQ Ding, G De Piccoli, J Torres-Rosell, A Losada, T Hirano, N Cobbe, E Revenkova, N Pezzi, A Bergerat, S Keeney, SB Malik, DK Bishop, A Shinohara, JY Masson, A Shinohara, DK Bishop, M Tarsounas, GV Petukhova, RJ Pezza, G Petukhova, M Shinohara, N Sarai, J Wesoly, GV Petukhova, C Zierhut, NY Stassen, Z Lin, J Jiricny, T Snowden, S Neyton, Z Lin, KM Culligan, TF Wang, M Raschle, GM Li, SM Baker, SM Lipkin, S Santucci-Darmanin, E Cannavo, PC Chen, P Pasierbek, S Yokobayashi, R Chenna, DR Maddison, F Ronquist, S Whelan   +115 more
core   +1 more source

Methicillin-Resistant Staphylococcus aureus Associated with Animals and Its Relevance to Human Health [PDF]

, 2012
Staphylococcus aureus is a typical human pathogen. Some animal S. aureus lineages have derived from human strains following profound genetic adaptation determining a change in host specificity.
Annalisa Pantosti
core   +2 more sources

Activation of Insula‐Accumbal Projection Neurons Is Required for Relapse‐Like Behaviour Following Opioid Self‐Administration

Addiction Biology, Volume 31, Issue 1, January 2026.
ABSTRACT The insular cortex (IC) is known to underlie drug seeking and relapse for multiple drug classes, yet the precise role the IC plays in opioid use disorder (OUD) remains unclear. In preclinical models of OUD, inhibition of the IC has produced conflicting results, such that in some cases the IC seems to promote opioid seeking whereas in others ...
Rachel E. Clarke, Bayleigh E. Pagoota, Isabella E. Dinu, Jacqueline E. Paniccia, Anna C. Tsyrulnikov, Annaka M. Westphal, Jade Baek, Michael D. Scofield, James M. Otis   +8 more
wiley   +1 more source