Results 91 to 100 of about 2,944 (276)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Equivalence Proof and Performance Analysis of Weighted Least Squares Residual Method and Weighted Parity Vector Method in RAIM

IEEE Access, 2019
Besides accuracy, integrity is another important performance measure of GNSS. The classical least-squares-residual (LSR) method and parity vector (PV) method are often used in the receiver autonomous integrity monitoring (RAIM).
Xiaping Ma, Kegen Yu, Jean-Philippe Montillet, Xiaoxing He   +3 more
doaj   +1 more source

Advanced Receiver Autonomous Integrity Monitoring and Local Effect Models for Rail, Maritime, and Unmanned Aerial Vehicles Sectors

Advanced Receiver Autonomous Integrity Monitoring (ARAIM) represents an advancement over RAIM, designed to utilize dual-frequency and multi-constellation technologies.
Fulgencio Buendía, Sophie Damy, Florin Mistrapau, Merle Snijders, Ginés Moreno, Juan Pablo Boyero, Javier Fidalgo, Javier de Toro, Enrique Domínguez, Roxana Clopot, Elena Labrador, Heiko Engwerda, Matteo Sgammini, Juliette Casals, Carlos Sanz, Ana Cezón   +15 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Availability evaluation and optimisation of advanced receiver autonomous integrity monitoring fault detection and exclusion considering temporal correlations

IET Radar, Sonar & Navigation
The Advanced Receiver Autonomous Integrity Monitoring (ARAIM) provides an Aircraft‐Based Augmentation System function for aircraft Global Navigation Satellite System equipment.
Jingtian Du, Kun Fang, Zhipeng Wang, Yanbo Zhu   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fast Protection Level for Precise Positioning Using PPP-RTK with Robust Adaptive Kalman Filter

Remote Sensing
Developing advanced receiver autonomous integrity monitoring (ARAIM) for ground real-time precise positioning applications such as autonomous vehicles presents computational challenges, particularly in calculating real-time protection levels (PLs) that ...
Hassan Elsayed, Ahmed El-Mowafy, Amir Allahvirdi-Zadeh, Kan Wang   +3 more
doaj   +1 more source

Rover autonomous integrity monitoring of GNSS RTK positioning solutions with multi-constellations

, 2009
This paper studies receiver autonomous integrity monitoring (RAIM) algorithms and performance benefits of RTK solutions with multiple-constellations. The proposed method is generally known as Multi-constellation RAIM -McRAIM.
Feng, Yanming, Wang, Charles, Wang, Jun
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source