Results 71 to 80 of about 2,944 (276)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Vision-Aided RAIM: A New Method for GPS Integrity Monitoring in Approach and Landing Phase

Sensors, 2015
In the 1980s, Global Positioning System (GPS) receiver autonomous integrity monitoring (RAIM) was proposed to provide the integrity of a navigation system by checking the consistency of GPS measurements.
Li Fu, Jun Zhang, Rui Li, Xianbin Cao, Jinling Wang   +4 more
doaj   +1 more source

Position-Domain Non-Gaussian Error Overbounding for ARAIM

Remote Sensing, 2020
The non-Gaussian observation error is a threat for advanced receiver autonomous integrity monitoring (ARAIM), because the protection level of ARAIM based on the Gaussian distribution assumption is insufficient to envelope the positioning error (PE), and ...
Lin Zhao, Jie Zhang, Liang Li, Fuxin Yang, Xiaosong Liu   +4 more
doaj   +1 more source

Integrity analysis for GPS-based navigation of UAVs in urban environment [PDF]

, 2020
The increasing use of Unmanned Aerial Vehicles (UAVs) in safety-critical missions in both civilian and military areas demands accurate and reliable navigation, where one of the key sources of navigation information is presented by Global Navigation ...
Ivan Petrunin, Hong, Juhyeon, Tsourdos, Antonios, Oguz Kagan Isik, Antonios Tsourdos, Isik, Oguz Kagan, Juhyeon Hong, Petrunin, Ivan   +7 more
core   +1 more source

Receiver Autonomous Integrity Monitoring Method Based on Digital Pictures Analysis

, 2010
The paper presents conception of receiver autonomous integrity monitoring (RAIM) method in urban areas based on digital pictures analysis. The results of considerations the system architecture and finale shape of mobile measurement station are described.
Nowak, A., Wąż, M.
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A New GNSS Integrity Monitoring Based on Channels Joint Characterization [PDF]

, 2016
International audienceMany GNSS (Global Navigation Satellites System) applications need high integrity performances. Receiver Autonomous Integrity Monitoring (RAIM), or similar method, is commonly used.
Israel, Jonathan, Aubault-Roudier, Marion, Barbiero, Franck, Carrie, Guillaume, Charbonnieras, Christophe, Ries, Lionel, Vincent, François   +6 more
core   +3 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source