Results 1 to 10 of about 3,264,523 (318)

Splicing heterogeneity: separating signal from noise

open access: yesGenome Biology, 2018
Single-cell analyses have revealed a tremendous variety among cells in the abundance and chemical composition of RNA. Much of this heterogeneity is due to alternative splicing by the spliceosome.
Yihan Wan, Daniel R. Larson
doaj   +1 more source

PancrESS – a meta-analysis resource for understanding cell-type specific expression in the human pancreas

open access: yesBMC Genomics
Background The human pancreas is composed of specialized cell types producing hormones and enzymes critical to human health. These specialized functions are the result of cell type-specific transcriptional programs which manifest in cell-specific gene ...
David Sturgill, Li Wang, H. Efsun Arda
doaj   +1 more source

TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide

open access: yesiScience, 2019
Summary: The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative, 5-carboxylcytosine (5caC), as a factor driving new CTCF binding within genomic DNA ...
Kyster K. Nanan   +6 more
doaj  

Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists

open access: yesCell Discovery, 2022
Hongmin Cai   +12 more
doaj   +1 more source

Arming HSV-Based Oncolytic Viruses with the Ability to Redirect the Host’s Innate Antiviral Immunity to Attack Tumor Cells

open access: yesMolecular Therapy: Oncolytics, 2020
One of the major hurdles for cancer immunotherapy is the host’s innate antiviral defense mechanisms. They include innate immune cells, such as natural killer (NK) cells and macrophages, which can be recruited within hours to the site of injection to ...
Xinping Fu   +3 more
doaj  

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