Results 111 to 120 of about 119,693 (290)

Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain.

Frontiers in Bioscience, 2008
The contribution of blockade of adenosine A1 and A2A receptor to the psychostimulant effects of caffeine is still a matter of debate. When analyzing motor activity in rats, acutely administered caffeine shows a profile of a non-selective adenosine ...
S. Ferré, F. Ciruela, J. Borycz, M. Solinas, D. Quarta, K. Antoniou, C. Quiroz, Z. Justinova, C. Lluis, R. Franco, S. Goldberg   +10 more
semanticscholar   +1 more source

Research Methodology in Acupuncture for Managing Interstitial Cystitis/Bladder Pain Syndrome: A Scoping Review

Neurourology and Urodynamics, EarlyView.
ABSTRACT Background Acupuncture and moxibustion are being explored as complementary therapies with promising potential in managing interstitial cystitis/bladder pain syndrome (IC/BPS). While some studies indicate possible benefits, their scientific basis and clinical efficacy remain subjects of debate, partly due to methodological flaws in study ...
Miguel Ángel Infantes Rosales, Ángeles Mesías Pesqueira, Astrid Castellanos Díaz, Esther Díaz Mohedo   +3 more
wiley   +1 more source

Adenosine Receptor Mechanisms Underlying Bladder Dysfunction in Male Rats With Bladder Outlet Obstruction

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims We examined the role of subtypes of adenosine receptors in bladder dysfunction and changes in the adenosine receptor expression in the bladder using male rats with partial bladder outlet obstruction (BOO). Methods In Sprague‐Dawley rats (male 8‐weeks old), BOO was produced by a partial ligation of the urethra along a metal rod of a 1.2 mm
Ei‐ichiro Takaoka, Masahiro Kurobe, Kanako Matsuoka, Tadanobu Kamijo, Shingo Kimura, Paul N. Watton, Anne M. Robertson, Naoki Yoshimura   +7 more
wiley   +1 more source

Role of A1 adenosine receptor in cardiovascular diseases: Bridging molecular mechanisms with therapeutic opportunities

Experimental and Molecular Pathology
Adenosine serves as a critical homeostatic regulator, exerting influence over physiological and pathological conditions in the cardiovascular system.
Warisara Parichatikanond, Ratchanee Duangrat, Narawat Nuamnaichati, Supachoke Mangmool   +3 more
doaj  

Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain [PDF]

, 1994
Three full-length cDNA clones encoding the guinea pig A1 adenosine receptor have been isolated by polymerase chain reaction (PCR) and low-stringency hybridization screening of a guinea pig brain cDNA library.
Arend, Bhattacharya, Cassel, Cronstein, Evoniuk, Fastbom, Feinberg, Ferkany, Furlong, Gantz, Gubler, Kozak, Kyte, Libert, Libert, Libert, Maenhaut, Mahan, Maruyama, Meng, Munson, Neumann, Okayama, Oksenberg, Olah, Pierce, Reppert, Saiki, Salvatore, Sambrook, Sanger, Stehle, Stiles, Stone, Takebe, Tucker, Williams, Zhou   +37 more
core   +1 more source

Dual acting antioxidant A1 adenosine receptor agonists

Bioorganic & Medicinal Chemistry Letters, 2007
Herein we report the synthesis and biological evaluation of some potent and selective A(1) adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety. N(6)-(2,2,5,5-Tetramethylpyrrolidin-1-yloxyl-3-ylmethyl)adenosine (VCP28, 2e) proved to be an agonist with high affinity (K(i)=50nM) and good selectivity (A ...
Gregg, Alison, Bottle, Steven, Devine, Shane, Figler, Heidi, Linden, Joel, White, Paul, Pouton, Colin, Urmaliya, Vijay, Scammells, Peter   +8 more
openaire   +4 more sources

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine

Journal of Pharmacological Sciences, 2005
The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata   +5 more
doaj  

Adenosine A_2A receptor binding profile of two antagonists, ST1535 and KW6002: consideration on the presence of atypical adenosine A_2A binding sites

Frontiers in Psychiatry, 2010
Adenosine A2A receptors seem to exist in typical (more in striatum) and atypical (more in hippocampus and cortex) subtypes. In the present study, we investigated the affinity of two adenosine A2A receptor antagonists, ST1535 [2 butyl -9-methyl-8-(2H-1,2 ...
Teresa Riccioni, Fabiana Leonardi, Franco Borsini   +2 more
doaj   +1 more source

New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile [PDF]

, 2007
A new series of 2,6,9-trisubstituted adenines (5–14) have been prepared and evaluated in radioligand binding studies for their affinity at the human A1, A2A and A3 adenosine receptors and in adenylyl cyclase experiments for their potency at the human A2B
A Lean De, AS Robeva, B Vidal, BB Fredholm, BL Fiebich, Catia Lambertucci, Chiara Bolcato, Dhuldeo D. Kachare, Diego Dal Ben, DL Boyle, DL Marquardt, E Camaioni, G Cristalli, G Cristalli, G Cristalli, G Pastorin, Giampiero Spalluto, Gloria Cristalli, I Feoktistov, I Feoktistov, I Feoktistov, I Feoktistov, Karl-Norbert Klotz, KN Klotz, KN Klotz, L Zhang, MJ Jacobson, MW Beukers, PG Baraldi, R Volpini, R Volpini, R Volpini, R Volpini, R Volpini, RK Dubey, Rosaria Volpini, RV Kalla, T Maruyama, YC Cheng, YC Kim   +39 more
core   +2 more sources