Results 91 to 100 of about 1,637,046 (206)

Repetitive stimulation of adenosine A1 receptors in vivo:Changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia

, 2008
Adenosine is an important neuromodulator and neuroprotective molecule, which is produced in the brain as a function of neuronal activity, coupling energy expenditure to energy supply. Under conditions of increased need and reduced availability of energy,
Roman, Viktor, Luiten, Paul G. M., Meerlo, Peter, Meerlo, Peter; id_orcid, Keijser, Johannes   +4 more
core   +1 more source

Adenosine A1 receptor (ADORA1) [PDF]

Science-Business eXchange, 2009
  +6 more sources

Age-related changes in A1 adenosine receptor mediated bradycardia

, 2000
The impact of age on functional sensitivity to A1-adenosine receptor activation was studied in Langendorff-perfused hearts from young (1-2 mo) and old (12-18 mo) male Wistar rats.
Headrick, JP, Rose'meyer, RB, Hinschen, AK   +2 more
core  

Potential differences in receptor‐mediated G‐protein activation in postmortem human hippocampal membranes prepared from healthy controls and suicide victims

Neuropsychopharmacology Reports
Aim Postmortem brain studies offer enormous opportunities to study molecular mechanisms associated with suicide. In the present study, conventional [35S]GTPγS binding assay and its version‐up method ([35S]GTPγS binding/immunoprecipitation assay) were ...
Yuji Odagaki, Masakazu Kinoshita, Miklós Palkovits, Dasiel Oscar Borroto‐Escuela, Kjell Fuxe   +4 more
doaj   +1 more source

Target screening and optimization of candidate compounds for breast cancer treatment using bioinformatics and computational chemistry approaches

Frontiers in Pharmacology
ObjectivesThis study aimed to identify critical therapeutic targets and design potent antitumor compounds for breast cancer treatment through an integrated bioinformatics and computational chemistry approach.MethodsWe conducted initial screening and ...
Jian Xu, Xue Li, Yiduo Jia, Yiduo Jia
doaj   +1 more source

Adenosine Receptor A1 [PDF]

, 2020
openaire   +1 more source

Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors

, 1992
Agonist-induced desensitization of adenosine A1 and A2 receptors was studied in rat striatum slices maintained in carbo-oxygenated Krebs buffer. Slices were exposed to adenosine analogues (either cyclo-pentyl-adenosine or N-ethyl-carboxamido-adenosine ...
Abbracchio MP, Cattabeni F, Fogliatto G, Rovati GE, Paoletti AM   +4 more
core  

Labelling of A1 and A3 adenosine receptors with the new selective A1 agonist 2'-Me-CCPA

, 1998
Brain is rich of adenosine receptors. Radiolabelled adenosine receptor agonists such as [3H]N6-cyclohexyladenosine ([3H]CHA) and [3H]phenylisopropyladenosine were largely used for labelling adenosine A1 receptor sites.
AMENTA, Francesco, FRANCHETTI, Palmarisa, CAPPELLACCI, Loredana, P. Barili, GRIFANTINI, Mario   +4 more
core   +1 more source

Pantoprazole as a potential repurposed drug targeting the adenosinergic system in esophageal cancer. [PDF]

Med Chem Res
Simioni A, Weimer RD, de Souza JB, Citrini IV, da Rosa JA, Cardoso K, Delawi ME, Timmers LF, Morrone FB.   +8 more
europepmc   +1 more source

From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits. [PDF]

Biosci Rep
Marques LB, de Carvalho A, Souza RLLDS, Viero FT, Britto LRG, Ulrich H.   +5 more
europepmc   +1 more source