Results 1 to 10 of about 184,381 (164)

Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats [PDF]

Frontiers in Pharmacology, 2019
Objective: The adenosinergic system may influence excitability in the brain. Endogenous and exogenous adenosine has anticonvulsant activity presumably by activating A1 receptors.
Petr Fabera, Petr Fabera, Martina Parizkova, Martina Parizkova, Libor Uttl, Libor Uttl, Katerina Vondrakova, Katerina Vondrakova, Hana Kubova, Grygoriy Tsenov, Grygoriy Tsenov, Pavel Mares   +11 more
doaj   +2 more sources

Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons [PDF]

Neural Regeneration Research, 2020
Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.
Yun-Cheng Lv, An-Bo Gao, Jing Yang, Li-Yuan Zhong, Bo Jia, Shu-Hui Ouyang, Le Gui, Tian-Hong Peng, Sha Sun, Francisco S Cayabyab   +9 more
doaj   +2 more sources

Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats

Frontiers in Aging Neuroscience, 2021
A previous study has demonstrated that pretreatment with electroacupuncture (EA) induces rapid tolerance to focal cerebral ischemia. In the present study, we investigated whether adenosine receptor 1 (A1 R) is involved in EA pretreatment-induced ...
Yiyi Shi, Qinxue Dai, Binbin Ji, Luping Huang, Xiuxiu Zhuang, Yunchang Mo, Junlu Wang   +6 more
doaj   +1 more source

Curcumin ameliorates lipid metabolic disorder and cognitive dysfunction via the ABCA1 transmembrane transport system in APP/PS1 double transgenic mice

Journal of Integrative Neuroscience, 2021
The disorder of lipid metabolism, especially cholesterol metabolism, can promote Alzheimer’s Disease. Curcumin can ameliorate lipid metabolic disorder in the brain of Alzheimer’s Disease patients, while the mechanism is not clear.
Mingyuan Tian, Fanlin Zhou, Zhipeng Teng, Chen Wang, Xiong Zhang, Yangyang Wang, Yu Li   +6 more
doaj   +1 more source

Suppression of annexin A1 and its receptor reduces herpes simplex virus 1 lethality in mice.

PLoS Pathogens, 2022
Herpes simplex virus 1 (HSV-1)-induced encephalitis is the most common cause of sporadic, fatal encephalitis in humans. HSV-1 has at least 10 different envelope glycoproteins, which can promote virus infection.
Li-Chiu Wang, Shang-Rung Wu, Hui-Wen Yao, Pin Ling, Guey-Chuen Perng, Yen-Chi Chiu, Sheng-Min Hsu, Shun-Hua Chen   +7 more
doaj   +1 more source

Multisite Model of Allosterism for the Adenosine A1 Receptor [PDF]

Journal of Chemical Information and Modeling, 2020
ABSTRACT Despite being a target for about one-third of approved drugs, G protein-coupled receptors (GPCRs) still represent a tremendous reservoir for therapeutic strategies against countless diseases. For example, several cardiovascular and central nervous systems conditions could benefit from clinical agents that ...
Giuseppe Deganutti, Kerry Barkan, Graham Ladds, Christopher A. Reynolds   +3 more
openaire   +2 more sources

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]

Journal of Histochemistry & Cytochemistry, 2000
The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
MINELLI, Alba, ALLEGRUCCI, Cinzia, Piomboni P., MANNUCCI, Roberta, Lluis C., Franco R.   +5 more
openaire   +4 more sources

Influence of adenosine receptor ligands on ketamine-induced anesthesia in mice

Current Issues in Pharmacy and Medical Sciences, 2012
The influence of adenosine receptor ligands on anesthetic activity of  ketamine was studied in mice. Ketamine-induced anesthesia (100 mg/kg) was significantly increased by the  higher doses of CPA (selective A1 adenosine receptor agonist) and NECA (A1 ...
Sylwia Fidecka, Marcin Mandryk
doaj   +1 more source

Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages

Emerging Microbes and Infections, 2021
Leptospirosis, caused by pathogenic Leptospira species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production.
Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo, Ping He   +10 more
doaj   +1 more source