Results 21 to 30 of about 1,660,729 (286)

Degranulation of rat omental mast cells by A1 receptor agonists in vitro

Mediators of Inflammation, 1996
The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
doaj   +1 more source

Dual acting antioxidant A1 adenosine receptor agonists [PDF]

, 2007
Herein we report the synthesis and biological evaluation of some potent and selective A1 adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety.
Figler, Heidi, Urmaliya, Vijay, Scammells, Peter J., Pouton, Colin W., Linden, Joel, Gregg, Alison D., Devine, Shane M., White, Paul, Bottle, Steven E.   +8 more
core   +1 more source

Laser irradiation activates spinal adenosine A1 receptor to alleviate osteoarthritis pain in monosodium iodoacetate injected rats [PDF]

Journal of Integrative Neuroscience, 2020
The analgesic role of the adenosine A1 receptor is thought to involve the modulation of the spinal N-methyl D-aspartate receptor-mediated nociceptive pathway, which is suggested to be an underlying mechanism in chronic pain.
Yuan Li, Fan Wu, Lixing Lao, Xueyong Shen
doaj   +1 more source

Products of oxidative stress and transient receptor potential ankyrin A1 expression in the brainstem after lung ischemia–reperfusion injury

Pulmonary Circulation, 2019
Lung ischemia–reperfusion injury is a common clinical concern. As the injury occurs, the pulmonary afferent nerves play a key role in regulating respiratory functions under pathophysiological conditions.
Xiaoying Gu, Yu Nan, Xiaochuan Pang, Wenwen Zhang, Jian Zhang, Yiyuan Zhang   +5 more
doaj   +1 more source

Extract and the Main Component, Cordycepin, Modulate the Functions of Prostate Cancer Cells Partially Through the Adenosine A1 Receptor

Natural Product Communications, 2022
Our previous study demonstrated that an extract of Cordyceps militaris (CM) derived from Samia Cynthia ricini inhibits testosterone-induced prostate hypertrophy in an animal model.
Kazuya Kusama, Takumi Suzuki, Ryosuke Motohashi, Takumi Nobusawa, Koichiro Ota, Mana Azumi, Mikihiro Yoshie, Hiroaki Miyaoka, Kazuhiro Tamura   +8 more
doaj   +1 more source

Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine [PDF]

, 2015
This work was funded by the Wellcome Trust Institutional Strategic Support Fund for University of St. Andrews.Despite considerable evidence that glia can release modulators to influence the excitability of neighbouring neurons, the importance of ...
Miles, Gareth B., David Acton, Acton David, Miles Gareth B., Acton, David, Gareth B Miles   +5 more
core   +2 more sources

Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]

, 2015
The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte, Miles, Gareth Brian, Nascimento, Filipe   +2 more
core   +1 more source

The role of cGMP on adenosine A1 receptor-mediated inhibition of synaptic transmission at the hippocampus

Frontiers in Pharmacology, 2016
Both adenosine A1 receptor and cGMP inhibit synaptic transmission at the hippocampus and recently it was found that A1 receptor increased cGMP levels in hippocampus, but the role of cGMP on A1 receptor-mediated inhibition of synaptic transmission remains
Isa ePinto, André eSerpa, Ana Maria Sebastião, Ana Maria Sebastião, José Francisco Cascalheira, José Francisco Cascalheira   +5 more
doaj   +1 more source

Role of A1 adenosine receptor in cardiovascular diseases: Bridging molecular mechanisms with therapeutic opportunities

Experimental and Molecular Pathology
Adenosine serves as a critical homeostatic regulator, exerting influence over physiological and pathological conditions in the cardiovascular system.
Warisara Parichatikanond, Ratchanee Duangrat, Narawat Nuamnaichati, Supachoke Mangmool   +3 more
doaj   +1 more source

Scavenger Receptor A1 Mediates the Uptake of Carboxylated and Pristine Multi-Walled Carbon Nanotubes Coated with Bovine Serum Albumin

Nanomaterials, 2021
Previously, we noted that carboxylated multi-walled carbon nanotubes (cMWNTs) coated with Pluronic® F-108 (PF108) bound to and were accumulated by macrophages, but that pristine multi-walled carbon nanotubes (pMWNTs) coated with PF108 were not (Wang et ...
Mai T. Huynh, Carole Mikoryak, Paul Pantano, Rockford Draper   +3 more
doaj   +1 more source