Results 11 to 20 of about 1,660,729 (286)
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists [PDF]
Molecules, 2015 The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
Donatella Callegari +7 more
doaj +2 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on EPHA1 (EPH receptor A1), with data on DNA, on the protein encoded, and where the gene is implicated.
Stringer, B +4 more
openaire +5 more sources
The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor. [PDF]
The EMBO Journal, 1991 The extensive amino acid sequence conservation among G protein-coupled receptors has been exploited to clone new members of this large family by homology screening or by PCR. Out of four such receptor cDNAs we cloned recently, RDC7 corresponds to a relatively abundant transcript in the brain cortex, the thyroid follicular cell and the testis.
Libert, Frédérick +7 more
openaire +4 more sources
The translational relevance of the Annexin A1 pathway in inflammatory pathologies: opportunities for novel therapeutic development [PDF]
, 2009 PhDEndogenous anti-inflammatory mediators form a complex network triggered in the host to dampen cell activation and promote resolution of inflammation.
Dalli, Jesmond
core +4 more sources
Regulación de receptores de neurotransmisores y neuromoduladores por proteínas estructurales [PDF]
, 2003 [cat] Los receptores acoplados a proteína G o de siete dominios transmembrana (GPCRs o 7TMR) constituyen la mayor superfamilia de receptores de membrana involucrados en la transducción de una señal extracelular al interior de la célula.
Burgueño Hurtado, Javier
core +6 more sources
Heterómeros de receptores de dopamina. Nuevos mecanismos para la regulación de la transmisión dopaminérgica [PDF]
, 2012 [spa] El Objetivo General de esta Tesis ha sido investigar la formación y función de heterómeros entre receptores de dopamina y otros receptores que puedan estar implicados en la regulación de la transmisión dopaminérgica, como receptores de galanina ...
Moreno Guillén, Estefanía
core +6 more sources
Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET [PDF]
, 2019 Background and Purpose: Adenosine is a local mediator that regulates a number of physiological and pathological processes via activation of adenosine A1‐receptors.
Samantha L. Cooper +11 more
core +1 more source
Frontiers in Cellular Neuroscience, 2018 It is well described that A1 adenosine receptors inhibit synaptic transmission at excitatory synapses in the brain, but the effect of adenosine on reciprocal synapses has not been studied so far.
Kristina Schulz +5 more
doaj +1 more source
, 2011 Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K. +3 more
core +1 more source
Journal of Pharmacological Sciences, 2004 Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone),
Takuya Maemoto +12 more
doaj +1 more source