Results 11 to 20 of about 1,719,750 (297)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on EPHA1 (EPH receptor A1), with data on DNA, on the protein encoded, and where the gene is implicated.
Stringer, B +4 more
openaire +5 more sources
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists [PDF]
Molecules, 2015 The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
Donatella Callegari +7 more
doaj +2 more sources
Degranulation of rat omental mast cells by A1 receptor agonists in vitro
Mediators of Inflammation, 1996 The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
doaj +2 more sources
The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor. [PDF]
The EMBO Journal, 1991 The extensive amino acid sequence conservation among G protein-coupled receptors has been exploited to clone new members of this large family by homology screening or by PCR. Out of four such receptor cDNAs we cloned recently, RDC7 corresponds to a relatively abundant transcript in the brain cortex, the thyroid follicular cell and the testis.
Libert, Frédérick +7 more
openaire +4 more sources
Structure of the BoNT/A1 – receptor complex
Toxicon, 2015 Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A--host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders.
Benoit, Roger M. +6 more
openaire +4 more sources
ALLOSTERIC MODULATORS OF THE A1 ADENOSINE RECEPTOR
, 2008 Title compd. I [R1 = H, (un)substituted alkyl, aryl or cycloalkyl; R2, R3 and R4 independently = H, halo, OH, NO2, CN, (un)substituted alkyl, aryl, cycloalkyl or alkoxy; Q = (un)substituted piperidinyl, azepinyl, 5-membered spirocyclic ring, etc.], and ...
BARALDI PIER GIOVANNI +2 more
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Brain Research, 2008 Adenosine is an important neuromodulator and neuroprotective molecule, which is produced in the brain as a function of neuronal activity, coupling energy expenditure to energy supply. Under conditions of increased need and reduced availability of energy, including hypoxia and prolonged wakefulness, there is an increase in adenosine turnover and ...
Roman, Viktor +3 more
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Multisite Model of Allosterism for the Adenosine A1 Receptor [PDF]
Journal of Chemical Information and Modeling, 2020 ABSTRACT Despite being a target for about one-third of approved drugs, G protein-coupled receptors (GPCRs) still represent a tremendous reservoir for therapeutic strategies against countless diseases. For example, several cardiovascular and central nervous systems conditions could benefit from clinical agents that ...
Giuseppe Deganutti +3 more
openaire +2 more sources
Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]
Journal of Histochemistry & Cytochemistry, 2000 The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
MINELLI, Alba +5 more
openaire +4 more sources
Dual acting antioxidant A1 adenosine receptor agonists [PDF]
, 2007 Herein we report the synthesis and biological evaluation of some potent and selective A1 adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety.
Figler, Heidi +8 more
core +1 more source