Results 81 to 90 of about 1,637,046 (206)

Allosteric Modulators of the A1 Adenosine receptor

, 2011
The present invention provides compounds active as allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor, such as treatment of pain, in particular chronic pain
ROMAGNOLI, Romeo, BARALDI, Pier Giovanni, A. R. Moorman   +2 more
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Cloning and functional characterization of a human A1 adenosine receptor.

, 1992
A human brain hippocampus cDNA library was screened by hybridization with a dog A1 adenosine receptor cDNA probe. Sequencing of the resulting clones identified a 978 residue open reading frame encoding a 326 amino acid polypeptide showing 95.7 ...
Libert, Frédérick, Czernilofsky, A, Dumont, Jacques, Lefort, Anne, Ensinger, H A, Mendla, K D, Vassart, Gilbert, Van Sande, Jacqueline   +7 more
core   +1 more source

Affinity and selectivity of tecadenoson, 2-chloro-tecadenoson and 2’-C-methyl analogues at bovine and pig A1 adenosine receptor

, 2005
Adenosine A1 receptor agonists have a great interest as neuroprotective agents for the treatment of glutamate-related neurodegenerative disorders and as antilipolytic agents.
PASQUALINI M., COSTA B., FRANCHETTI, Palmarisa, KLOTZ K., CAPPELLACCI, Loredana, VITA, PATRIZIA, PETRELLI, Riccardo, MARTINI C., SPINETTI F., LAVECCHIA A., GRIFANTINI, Mario   +10 more
core   +1 more source

N6-substituted C5′-modified adenosines as A1 adenosine receptor agonists

, 2008
N6-substituted C5′-modified adenosines as A1 adenosine receptor ...
S Baker (9861626), Sally Hutchinson (13051977), Trent Ashton (13097196), Peter Scammells (13051092)   +3 more
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Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]

, 2007
[spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core   +2 more sources

2’-C-Methyl derivatives of tecadenoson and 2-chloro-tecadenoson with increased selectivity for human A1 adenosine receptor

, 2006
Adenosine mediates its pysiological effects through four G protein-coupled receptors (A1, A2A, A2B and A3). A large number of agonists with high affinity at A1, A2A, A3 adenosine receptors and moderate affinity at A2B receptor have been developed over ...
MARTINI C, FRANCHETTI, Palmarisa, LAVECCHIA A, CAPPELLACCI, Loredana, KLOTZ K. N, VITA, PATRIZIA, PETRELLI, Riccardo, PASQUALINI M, GRIFANTINI, Mario, COSTA B, SPINETTI F   +10 more
core   +1 more source

Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion

Basic and Clinical Neuroscience, 2013
Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide.
Mohmmad Zamani, M. Katebi, Mehdi Mehdizadeh, Laya Kafami, Fatemeh Malek, Mansooreh Soleimani   +5 more
doaj  

Adenosine A1 receptor-mediated antiadrenergic effects are modulated by A2a receptor activation in rat heart

, 2008
Presently, the physiological significance of myocardial adenosine A2a receptor stimulation is unclear. In this study, the influence of adenosine A2a receptor activation on A1 receptor-mediated antiadrenergic actions was studied using constant-flow ...
Honeyman, Thomas W., McGinn, Robert J., Meyer, Theo E., Woodiwiss, Angela J., Norton, Gavin R., Dobson, James G., Fenton, Richard A., Chung, Eugene S., Lorbar, Mojca   +8 more
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Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism

, 1992
The effects of adenosine in the nonischemic heart have been shown to be mediated via its binding to extracellular adenosine A1 and A2 receptors located predominantly on myocytes and endothelial cells, respectively.
R. D. Lasley, R. M. Mentzer
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Efeito da acupuntura no modelo de dor pós-operatória em camundongos: investigação do sistema adenosinérgico utilizando a farmacopuntura [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasA acupuntura é uma modalidade terapêutica comumente utilizada no tratamento da dor.
Moré, Ari Ojeda Ocampo
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