Results 71 to 80 of about 1,637,046 (206)

Atividade antinociceptiva da inosina em camundongos: participação dos receptores A1 e A2A [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA inosina, um nucleosídeo endógeno, e o primeiro metabolito da adenosina, e e sintetizada atraves da adenosina pela ...
Nascimento, Francisney Pinto do
core  

Age-related changes in cardiac adenosine receptor expression

, 2004
Adenosine is an important cardioprotective agent that works via several adenosine receptor (ADOR) subtypes to regulate cardiovascular activity. It is well established that functional responses to adenosine decline with age.
Jenner, Tamsin L., Mellick, AS, Mellick, Albert S., Jenner, TL, Rose’Meyer, Roselyn B., Harrison, Glenn J., Griffiths, Lyn R., Griffiths, LR, Harrison, GJ, Rose'Meyer, RB   +9 more
core   +1 more source

Adenosine A_2A receptor binding profile of two antagonists, ST1535 and KW6002: consideration on the presence of atypical adenosine A_2A binding sites

Frontiers in Psychiatry, 2010
Adenosine A2A receptors seem to exist in typical (more in striatum) and atypical (more in hippocampus and cortex) subtypes. In the present study, we investigated the affinity of two adenosine A2A receptor antagonists, ST1535 [2 butyl -9-methyl-8-(2H-1,2 ...
Teresa Riccioni, Fabiana Leonardi, Franco Borsini   +2 more
doaj   +1 more source

Efficient Synthesis of AMP579, a Novel Adenosine A1/A2 Receptor Agonist

, 2016
Efficient Synthesis of AMP579, a Novel Adenosine A1/A2 Receptor ...
Tory H. Powner (3026433), Larry K. Truesdale (3026427), Adam W. Sledeski (3026424), Gregory G. Kubiak (3026430), Michael K. O'Brien (2717263), Matthew R. Powers (3026421)   +5 more
core   +1 more source

The Selective Antagonism of Adenosine A2B Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro

Frontiers in Pharmacology, 2018
Ischemia is a multifactorial pathology characterized by different events evolving in time. Immediately after the ischemic insult, primary brain damage is due to the massive increase of extracellular glutamate.
Irene Fusco, Filippo Ugolini, Daniele Lana, Elisabetta Coppi, Ilaria Dettori, Lisa Gaviano, Daniele Nosi, Federica Cherchi, Felicita Pedata, Maria G. Giovannini, Anna M. Pugliese   +10 more
doaj   +1 more source

Adenosine analogues prevent phorbol ester-induced PKC depletion in porcine coronary artery via A1 receptor

, 1995
This study was undertaken to determine the adenosine receptor involved in the modulation of protein kinase C (PKC) in porcine coronary artery. Endothelium-denuded arterial rings were incubated with phorbol 12,13-dibutyrate (PDBu) in the presence or ...
S. J. Mustafa, R. B. Marala
core   +1 more source

Development of adenosine signalling in the cerebellum [PDF]

The release and clearance of adenosine are reasonably well-documented in the mature CNS but relatively little is known about how adenosine signalling changes during postnatal development.
Atterbury, Alison
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Role of adenosine in the antiepileptic effects of deep brain stimulation

Frontiers in Cellular Neuroscience, 2014
Despite the effectiveness of anterior thalamic nucleus (AN) deep brain stimulation (DBS) for the treatment of epilepsy, mechanisms responsible for the antiepileptic effects of this therapy remain elusive.
Maisa eMiranda, Clement eHamani, Clement eHamani, Antonio-Carlos eAlmeida, Beatriz eAmorim, Carlos eMacedo, Maria Jose eFernandes, Jose eNobrega, Mayra eAarao, Ana Paula eAntonio, Antonio eRodrigues, Monica L Andersen, Sergio eTufik, Luiz E Mello, Luciene eCovolan   +14 more
doaj   +1 more source

Diuretic and saliuretic effects of 1,3-dipropyl-8-cyclopentylxanthine, a selective A1-adenosine receptor antagonist

, 1991
We have previously shown that 8-phenyltheophylline (8-PT), a non-selective antagonist at adenosine A1-and A2-receptors, has a diuretic effect. In this study, the diuretic and adenosine antagonist effects of the A1-receptor selective compound 1,3-dipropyl-
J R Keddie, M G Collis, G Shaw
core   +1 more source

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Frontiers in Pharmacology
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi, Hervé Daniel, Heather McLean   +2 more
doaj   +1 more source