Results 131 to 140 of about 119,693 (290)
Anxiolytic properties of A1 adenosine receptor PAMs
Oncotarget, 2016 Anxiolytic properties of A1 adenosine receptor ...
VINCENZI, Fabrizio +2 more
openaire +4 more sources
Aging Cell, Volume 24, Issue 4, April 2025.Mitochondrial dysfunction is associated with senescence, the latter proving detrimental to mesenchymal stem cell (MSC)‐based strategies. We induced the expression of nuclear respiratory factor‐1 (NRF1), a driver of mitochondrial biogenesis, to metabolically potentiate MSCs and stave off senescence.
Hyunho Lee +6 more
wiley +1 more source
Role of adenosine in the antiepileptic effects of deep brain stimulation
Frontiers in Cellular Neuroscience, 2014 Despite the effectiveness of anterior thalamic nucleus (AN) deep brain stimulation (DBS) for the treatment of epilepsy, mechanisms responsible for the antiepileptic effects of this therapy remain elusive.
Maisa eMiranda +14 more
doaj +1 more source
Aging Cell, Volume 24, Issue 4, April 2025.Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Guan‐Jie Li +6 more
wiley +1 more source
Journal of Neuroscience, 2006 Adenosine is arguably the most potent and widespread presynaptic modulator in the CNS, yet adenosine receptor signal transduction pathways remain unresolved.
Tyson B. Brust +3 more
semanticscholar +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
Journal of Neuroscience, 1997 Adenosine A1 receptors induce an inhibition of adenylyl cyclase via G-proteins of the Gi/o family. In addition, simultaneous stimulation of A1 receptors and of receptor-mediated activation of phospholipase C (PLC) results in a synergistic potentiation of
K. Biber +4 more
semanticscholar +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Basic and Clinical Neuroscience, 2013 Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide.
Mohmmad Zamani +5 more
doaj
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source