Results 151 to 160 of about 1,637,046 (206)
A safety consideration in EP lab: Dramatic prolongation of adenosine induced AV-block in presence of ticagrelor. [PDF]
HeartRhythm Case RepSingh V, Krishnappa D, Padmanabhan D.
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Adenosine A1 receptor antagonists and the kidney
Current Opinion in Nephrology and Hypertension, 2003This review will examine the most recent evidence that adenosine receptors in the kidney can alter kidney function. Adenosine A(1)-receptors located in the afferent arteriole and proximal tubule can contribute to fluid retaining disorders by mediating tubuloglomerular feedback, afferent arteriole vasoconstriction or direct sodium absorption.
Paul S, Modlinger, William J, Welch
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Adenosine A1 receptors and erythropoietin production
American Journal of Physiology-Cell Physiology, 1993N6-cyclopentyladenosine (CPA), a selective adenosine A1 receptor agonist, in a concentration range of 10(-9) to 10(-7) M, produced a significant decrease in erythropoietin (EPO) levels in a human hepatocellular carcinoma (Hep G2) cell culture (medium levels of EPO, 91.81 +/- 1.61 and 94.36 +/- 0.97% of control, respectively) after 24 h incubation in a
T, Ohigashi, J, Brookins, J W, Fisher
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European Journal of Pharmacology, 1997
The pineal organ of vertebrates produces melatonin and adenosine. In lower vertebrates, adenosine modulates melatonin production. We report herein that 2-chloro-cyclopentyl-[3H]-adenosine ([3H]CCPA: adenosine A1 receptor agonist) and [3H]-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX: adenosine A1 receptor antagonist), bind specifically to sheep pineal ...
Falcon, J., Privat, K., Ravault, J.P.
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The pineal organ of vertebrates produces melatonin and adenosine. In lower vertebrates, adenosine modulates melatonin production. We report herein that 2-chloro-cyclopentyl-[3H]-adenosine ([3H]CCPA: adenosine A1 receptor agonist) and [3H]-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX: adenosine A1 receptor antagonist), bind specifically to sheep pineal ...
Falcon, J., Privat, K., Ravault, J.P.
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Allosteric modulation of A1-adenosine receptor: a review
Drug Discovery Today: Technologies, 2013Allosteric modulators of adenosine receptors represent an alternative to direct-acting adenosine agonists and nucleoside uptake blockers, preferably those can selectively modulate the response to adenosine in only those organs or localized areas of a given organ in which production of adenosine is increased.
M. Kimatrai Salvador +2 more
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Binding thermodynamics at A1 and A2a adenosine receptors
Life Sciences, 1996Only recently the binding equilibrium of a number of ligands at adenosine A1 and A2a receptors has been analyzed from a thermodynamic point of view. This approach presents the advantage, with respect to usual affinity constant measurements, of a greater capability to give information about the molecular mechanisms underlying the binding process.
BOREA, Pier Andrea +4 more
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The role of adenosine A1 receptor on immune cells
Inflammation Research, 2022Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A1, A2A, A2B, and A3), plays an important role under physiological and pathological conditions. As the receptor with the highest affinity for adenosine, the role of adenosine A1 receptor (A1R)-mediated adenosine signaling pathway in the ...
Lingyu, Zhong, Qiao, Peng, Xun, Zeng
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Allosteric Enhancers for A1 Adenosine Receptor
Mini-Reviews in Medicinal Chemistry, 2007Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents.
BARALDI, Pier Giovanni +9 more
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Cardiovascular toxicology, 2004
Adenosine has often been cited as a universal retaliatory metabolite against the destructive cellular mechanisms that are initiated during metabolic/oxidative stress. Despite this billing, clinical application of adenosine has been limited to rather specific cardiovascular indications (e.g., paroxysmal supraventricular tachycardia).
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Adenosine has often been cited as a universal retaliatory metabolite against the destructive cellular mechanisms that are initiated during metabolic/oxidative stress. Despite this billing, clinical application of adenosine has been limited to rather specific cardiovascular indications (e.g., paroxysmal supraventricular tachycardia).
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Effects of enprofylline on A1 and A2 adenosine receptors
European Journal of Pharmacology, 1985The effects of enprofylline were studied on A1 adenosine receptors of rat fat cells and on A2 adenosine receptors of human platelets and of guinea-pig lung. Enprofylline antagonized the 5'-N-ethylcarboxamidoadenosine (NECA)-induced stimulation of platelet adenylate cyclase activity with a KB of 130 microM.
D, Ukena, C G, Schirren, U, Schwabe
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