Results 101 to 110 of about 181,641 (286)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Acute Urinary Bladder Distension Triggers ICAM-1-mediated Renal Oxidative Injury via the Norepinephrine–renin–angiotensin II System in Rats

Journal of the Formosan Medical Association, 2009
Acute urinary bladder distension (AUBD) can activate bladder mechanical afferent and renal sympathetic nerves, which contributes to renal vasoconstriction.
Show-Shing Chen, Wang-Chuan Chen, Satoshi Hayakawa, Ping-Chia Li, Chiang-Ting Chien   +4 more
doaj   +1 more source

Versatility of the Angiotensin II Type 1 Receptor [PDF]

Circulation Research, 1998
This issue of Circulation Research includes 3 interesting studies that represent new concepts of AT1 receptor–mediated cell signaling in the cardiovascular system, which is currently of intense interest. The AT1 receptor mediates many important cardiovascular responses, including vasoconstriction, vascular and cardiac remodeling (cell proliferation ...
openaire   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Molecular-genetic assessment of angiotensin-converting enzyme hyperactivity determinancy risk at hemorrhagic fever with renal syndrome [PDF]

Саратовский научно-медицинский журнал, 2010
The research aimed to explore the changes of angiotensin-converting enzyme (ACE) blood activity and polymorphism of the angiotensin II type 1 receptor gene as disease predictor at hemorrhagic fever with renal syndrome (HFRS). In exami¬nation 409 patients
A.A. Baygildina, D.V. Islamgulov, F.Kh. Kamilov, T.A. Khabelova, I.R. Minniakhmetov   +4 more
doaj  

Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death

Cellular Physiology and Biochemistry, 2018
Background/Aims: MicroRNAs (miRNAs) play an essential role in the tumorigenesis of osteosarcoma (OS). However, the effects of miR-1248 on chemo-resistant potential of OS have not been studied. Here, we addressed this question.
Yue Zhao, Kaicheng Xu, Peng Liu
doaj   +1 more source

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk

Pharmacogenomics and Personalized Medicine, 2022
Linfa Chen,1,2,* Ying Wang,1,3,* Yajun Wang,4,* Shaoting Huang,1,3 Zhaochun Wu,1,3 Jiawen He,1,3 Wangtao Zhong,3 Bin Zhao,1,3 Guoda Ma,1,4 You Li1,5 1Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital ...
Chen L, Wang Y, Wang Y, Huang S, Wu Z, He J, Zhong W, Zhao B, Ma G, Li Y   +9 more
doaj  

Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor

Stem Cell Research, 2017
Obesity is often associated with high systemic and local activity of renin-angiotensin system (RAS). Mesenchymal stem cells of adipose tissue are the main source of adipocytes.
Veronika Y. Sysoeva, Liudmila V. Ageeva, Pyotr A. Tyurin-Kuzmin, George V. Sharonov, Daniyar T. Dyikanov, Natalia I. Kalinina, Vsevolod A. Tkachuk   +6 more
doaj   +1 more source

Hepatic Mitochondrial Renin-Angiotensin Systems

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core