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Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters, 2008Cannabinoid CB1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and related metabolic disorders were reported in 2001. To further evaluate the properties of CB receptors, we have designed a new series of tetrazole-biarylpyrazoles.
Suk Youn, Kang +6 more
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Pharmacology of cannabinoid CB1 and CB2 receptors
Pharmacology & Therapeutics, 1997There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 receptors in certain peripheral tissues. The existence of endogenous cannabinoid receptor agonists has also been demonstrated.
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