Results 1 to 10 of about 11,357 (146)

Cannabinoid receptor CB2 modulates axon guidance. [PDF]

open access: yesPLoS ONE, 2013
Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff   +8 more
doaj   +5 more sources

CB2 cannabinoid receptor as potential target against Alzheimer’s disease [PDF]

open access: yesFrontiers in Neuroscience, 2016
The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules and receptors involved in the homeostatic control of several physiological functions.
Ester eAso, Isidro eFerrer
doaj   +4 more sources

Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease

open access: yesFrontiers in Pharmacology, 2022
The distribution and roles of the cannabinoid CB2 receptor in the CNS are still a matter of debate. Recent data suggest that, in addition to its presence in microglial cells, the CB2 receptor may be also expressed at low levels, yet biologically relevant,
Samuel Ruiz de Martín Esteban   +19 more
doaj   +1 more source

Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. [PDF]

open access: yesPLoS ONE, 2007
Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate.
Shuxian Jiang   +8 more
doaj   +1 more source

Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. [PDF]

open access: yesPLoS ONE, 2016
Metabolic syndrome (MS) is a known risk factor for lower urinary tract symptoms. This study investigates whether functional and expression changes of cannabinoid CB1 and CB2 receptors are involved in the bladder dysfunction in an obese rat model with ...
Igor Blaha   +10 more
doaj   +1 more source

Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms

open access: yesCells, 2023
Cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) are components in the endocannabinoid system that play significant roles in regulating immune responses. There are many agonists for the cannabinoid receptors; however, their effects on T cell
Nuchjira Takheaw   +4 more
doaj   +1 more source

Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits

open access: yesFrontiers in Neuroscience, 2022
Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role in regulating neuronal function in the central nervous system.
Anthony S. Ferranti   +2 more
doaj   +1 more source

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

open access: yesFrontiers in Pharmacology, 2022
Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach   +10 more
doaj   +1 more source

Spontaneous Cannabinoid Receptor 2 (CB2) Expression in the Cochlea of Adult Albino Rat and Its Up-Regulation after Cisplatin Treatment. [PDF]

open access: yesPLoS ONE, 2016
We provide evidence for the presence of cannabinoid CB2 receptors in some cellular types of the cochlea of the adult albino rat. Cannabinoids and their receptors are increasingly being studied because of their high potential for clinical use.
Sergio Martín-Saldaña   +8 more
doaj   +1 more source

Expression and Functions of the CB2 Receptor in Human Leukocytes

open access: yesFrontiers in Pharmacology, 2022
The cannabinoid CB2 receptor was cloned from the promyeloid cell line HL-60 and is notably expressed in most, if not all leukocyte types. This relatively restricted localization, combined to the absence of psychotropic effects following its activation ...
Mélissa Simard   +10 more
doaj   +1 more source

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