Results 151 to 160 of about 11,404 (192)

Brain Cannabinoid CB2 Receptor in Schizophrenia

Biological Psychiatry, 2010
Neural endocannabinoid function appears to be involved in schizophrenia. Two endocannabinoid receptors, CB1 and CB2, are found in the brain and elsewhere in the body. We investigated roles of CB2 in schizophrenia.An association study was performed between tag single nucleotide polymorphisms (SNPs) in the CNR2 gene encoding the CB2 receptor and ...
Hiroki, Ishiguro, Yasue, Horiuchi, Maya, Ishikawa, Minori, Koga, Keiko, Imai, Yoshimi, Suzuki, Miyuki, Morikawa, Toshiya, Inada, Yuichiro, Watanabe, Makoto, Takahashi, Toshiyuki, Someya, Hiroshi, Ujike, Nakao, Iwata, Norio, Ozaki, Emmanuel S, Onaivi, Hiroshi, Kunugi, Tsukasa, Sasaki, Masanari, Itokawa, Makoto, Arai, Kazuhiro, Niizato, Shyuji, Iritani, Izumi, Naka, Jun, Ohashi, Akiyoshi, Kakita, Hitoshi, Takahashi, Hiroyuki, Nawa, Tadao, Arinami   +26 more
openaire   +2 more sources

CB2 cannabinoid receptor mediation of antinociception

Acute Pain, 2006
Management of acute pain remains a significant clinical problem. In preclinical studies, CB2 cannabinoid receptor-selective agonists inhibit nociception without producing central nervous system side effects. The CB2 receptor-selective agonist AM1241 produces antinociceptive effects that are antagonized by CB2, but not CB1, receptor-selective ...
Mohab M, Ibrahim, Megan L, Rude, Nicola J, Stagg, Heriberto P, Mata, Josephine, Lai, Todd W, Vanderah, Frank, Porreca, Nancy E, Buckley, Alexandros, Makriyannis, T Philip, Malan   +9 more
openaire   +2 more sources

CB2 cannabinoid receptor-mediated peripheral antinociception

Pain, 2001
Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence implicates the CB(1) receptor in the production of antinociception. However, the capacity of CB(2) receptors, which are located outside the central nervous system (CNS), to produce antinociception is not known.
Philip T, Malan, Mohab M, Ibrahim, Hongfeng, Deng, Qian, Liu, Heriberto P, Mata, Todd, Vanderah, Frank, Porreca, Alexandros, Makriyannis   +7 more
openaire   +2 more sources

CNS Effects of CB2 Cannabinoid Receptors

The Open Neuropsychopharmacology Journal, 2009
Cannabinoids, endocannabinoids and marijuana use activates two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs. The expression of CB1-Rs in the brain and periphery has been well studied, but CB2-Rs have received much less attention than CB1-Rs.
Emmanuel S. Onaivi, Hiroki Ishiguro, Qing-Rong Liu, Jian-Ping Gong, Patricia Tagliaferro, Alicia Brusco, Tadao Arinami, George R. Uhl   +7 more
openaire   +1 more source

Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2008
Sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Starting from a screening hit 8 that had modest affinity for the cannabinoid CB(2) receptor, a parallel synthesis approach and initial SAR are described, leading to compound 27 with 120-fold functional selectivity for the CB(2) receptor.
Karin, Worm, Q Jean, Zhou, Christopher T, Saeui, Rosalyn C, Green, Joel A, Cassel, Gabriel J, Stabley, Robert N, DeHaven, Nathalie, Conway-James, Christopher J, LaBuda, Michael, Koblish, Patrick J, Little, Roland E, Dolle   +11 more
openaire   +2 more sources

Ultrastructural Localization of Neuronal Brain CB2 Cannabinoid Receptors

Annals of the New York Academy of Sciences, 2008
The functional expression of neuronal CB2 cannabinoid receptors (CB2‐Rs) in the brain has been controversial. We and others have now demonstrated that CB2‐Rs are expressed in neurons and glial cells in the brain. However, the subcellular localization of these receptors has not been characterized.
A, Brusco, P A, Tagliaferro, T, Saez, E S, Onaivi   +3 more
openaire   +2 more sources

Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain

Brain Research, 2006
Brain expression of CB2 cannabinoid receptors has been much less well established and characterized in comparison to the expression of brain CB1 receptors. Since CB2 receptors are intensely expressed in peripheral and immune tissues, expression in brain microglia has been anticipated.
Jian-Ping, Gong, Emmanuel S, Onaivi, Hiroki, Ishiguro, Qing-Rong, Liu, Patricia A, Tagliaferro, Alicia, Brusco, George R, Uhl   +6 more
openaire   +2 more sources

Pharmacology of cannabinoid CB1 and CB2 receptors

Pharmacology & Therapeutics, 1997
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 receptors in certain peripheral tissues. The existence of endogenous cannabinoid receptor agonists has also been demonstrated.
openaire   +2 more sources

Expression of CB2 cannabinoid receptor in Pichia pastoris

Protein Expression and Purification, 2002
To facilitate purification and structural characterization, the CB2 cannabinoid receptor is expressed in methylotrophic yeast Pichia pastoris. The expression plasmids were constructed in which the CB2 gene is under the control of the highly inducible promoter of P. pastoris alcohol oxidase 1 gene. A c-myc epitope and a hexahistidine tag were introduced
Wenke, Feng, Jian, Cai, William M, Pierce, Zhao-Hui, Song   +3 more
openaire   +2 more sources

Novel Cannabinol Probes for CB1 and CB2 Cannabinoid Receptors

Journal of Medicinal Chemistry, 2000
The observation that the phenolic hydroxyl of THCs was important for binding to the CB1 receptor but not as critical for binding to the CB2 receptor prompted us to extend this finding to the cannabinol (CBN) series. To study the SAR of CBN analogues, CBN derivatives with substitution at the C-1, C-3, and C-9 positions were chosen since these positions ...
A, Mahadevan, C, Siegel, B R, Martin, M E, Abood, I, Beletskaya, R K, Razdan   +5 more
openaire   +2 more sources