Results 171 to 180 of about 1,265,475 (213)

Cannabinoid Receptor 2 (CB2)

2021
CB2 receptor was once considered to be the “peripheral cannabinoid receptor.” This label was based on its discovery and abundant expression in the immune system and, until recently, absence from the central nervous system. It is now accepted that CB2 receptors are expressed in the central nervous system as well. CB2 receptors have been expressed in the
Glenn R. Rech, Samer N. Narouze
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CB2 cannabinoid receptor mediation of antinociception

Acute Pain, 2006
Management of acute pain remains a significant clinical problem. In preclinical studies, CB2 cannabinoid receptor-selective agonists inhibit nociception without producing central nervous system side effects. The CB2 receptor-selective agonist AM1241 produces antinociceptive effects that are antagonized by CB2, but not CB1, receptor-selective ...
Mohab M, Ibrahim, Megan L, Rude, Nicola J, Stagg, Heriberto P, Mata, Josephine, Lai, Todd W, Vanderah, Frank, Porreca, Nancy E, Buckley, Alexandros, Makriyannis, T Philip, Malan   +9 more
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Antifibrogenic role of the cannabinoid receptor CB2 in the liver

Gastroenterology, 2005
Hepatic myofibroblasts are central for the development of liver fibrosis associated with chronic liver diseases, and blocking their accumulation may prevent fibrogenesis. Cannabinoids are the active components of marijuana and act via 2 G-protein-coupled receptors, CB1 and CB2.
Boris, Julien, Pascale, Grenard, Fatima, Teixeira-Clerc, Jeanne Tran, Van Nhieu, Liying, Li, Meliha, Karsak, Andreas, Zimmer, Ariane, Mallat, Sophie, Lotersztajn   +8 more
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Pharmacology of cannabinoid CB1 and CB2 receptors

Pharmacology & Therapeutics, 1997
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 receptors in certain peripheral tissues. The existence of endogenous cannabinoid receptor agonists has also been demonstrated.
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Expression of CB2 cannabinoid receptor in Pichia pastoris

Protein Expression and Purification, 2002
To facilitate purification and structural characterization, the CB2 cannabinoid receptor is expressed in methylotrophic yeast Pichia pastoris. The expression plasmids were constructed in which the CB2 gene is under the control of the highly inducible promoter of P. pastoris alcohol oxidase 1 gene. A c-myc epitope and a hexahistidine tag were introduced
Wenke, Feng, Jian, Cai, William M, Pierce, Zhao-Hui, Song   +3 more
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CB2 cannabinoid receptor-mediated peripheral antinociception

Pain, 2001
Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence implicates the CB(1) receptor in the production of antinociception. However, the capacity of CB(2) receptors, which are located outside the central nervous system (CNS), to produce antinociception is not known.
Philip T, Malan, Mohab M, Ibrahim, Hongfeng, Deng, Qian, Liu, Heriberto P, Mata, Todd, Vanderah, Frank, Porreca, Alexandros, Makriyannis   +7 more
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CNS Effects of CB2 Cannabinoid Receptors

The Open Neuropsychopharmacology Journal, 2009
Cannabinoids, endocannabinoids and marijuana use activates two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs. The expression of CB1-Rs in the brain and periphery has been well studied, but CB2-Rs have received much less attention than CB1-Rs.
Emmanuel S. Onaivi, Hiroki Ishiguro, Qing-Rong Liu, Jian-Ping Gong, Patricia Tagliaferro, Alicia Brusco, Tadao Arinami, George R. Uhl   +7 more
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Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands

Bioorganic & Medicinal Chemistry Letters, 2008
Sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Starting from a screening hit 8 that had modest affinity for the cannabinoid CB(2) receptor, a parallel synthesis approach and initial SAR are described, leading to compound 27 with 120-fold functional selectivity for the CB(2) receptor.
Karin, Worm, Q Jean, Zhou, Christopher T, Saeui, Rosalyn C, Green, Joel A, Cassel, Gabriel J, Stabley, Robert N, DeHaven, Nathalie, Conway-James, Christopher J, LaBuda, Michael, Koblish, Patrick J, Little, Roland E, Dolle   +11 more
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Novel Cannabinol Probes for CB1 and CB2 Cannabinoid Receptors

Journal of Medicinal Chemistry, 2000
The observation that the phenolic hydroxyl of THCs was important for binding to the CB1 receptor but not as critical for binding to the CB2 receptor prompted us to extend this finding to the cannabinol (CBN) series. To study the SAR of CBN analogues, CBN derivatives with substitution at the C-1, C-3, and C-9 positions were chosen since these positions ...
A, Mahadevan, C, Siegel, B R, Martin, M E, Abood, I, Beletskaya, R K, Razdan   +5 more
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Role of cannabinoid CB2 receptors in glucose homeostasis in rats

European Journal of Pharmacology, 2007
Here we show that the activation of cannabinoid CB2 receptors improved glucose tolerance after a glucose load. Blockade of cannabinoid CB2 receptors counteracted this effect, leading to glucose intolerance. Since blockade of cannabinoid CB1 receptors mimics the actions of cannabinoid CB2 receptor agonists, we propose that the endocannabinoid system ...
Francisco Javier, Bermudez-Silva, Irene, Sanchez-Vera, Juan, Suárez, Antonia, Serrano, Esther, Fuentes, Pablo, Juan-Pico, Angel, Nadal, Fernando, Rodríguez de Fonseca   +7 more
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