Results 11 to 20 of about 11,404 (192)
FEBS Open BioIntracellular Ca2+ regulates insulin secretion from pancreatic β‐cells and is influenced by cannabinoid signaling. However, the hydrophobicity and complex pharmacology of cannabinoid ligands prevent precision receptor targeting, limiting our ...
Alexander E. G. Viray, James A. Frank
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Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells [PDF]
PeerJ, 2019 Background Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC) over
Shivani Sachdev +4 more
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Peripheral cannabinoid receptor, CB2, regulates bone mass [PDF]
Proceedings of the National Academy of Sciences, 2006 The endogenous cannabinoids bind to and activate two G protein-coupled receptors, the predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid receptor type 2 (CB2). Whereas CB1 mediates the cannabinoid psychotropic, analgesic, and orectic effects, CB2 has been implicated recently in the regulation of liver fibrosis and ...
Ofek, Orr +12 more
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Cannabinoid receptor 2 signal promotes type 2 immunity in the lung
Cell Insight, 2023 Type 2 immunity in the lung protects against pathogenic infection and facilitates tissue repair, but its dysregulation may lead to severe human diseases. Notably, cannabis usage for medical or recreational purposes has increased globally.
Tingting Liu +6 more
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Frontiers in Veterinary Science, 2019 Growing evidence indicates cannabinoid receptors as potential therapeutic targets for chronic pain. Consequently, there is an increasing interest in developing cannabinoid receptor agonists for treating human and veterinary pain. To better understand the
Roberto Chiocchetti +9 more
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Expression of the endocannabinoid receptors in human fascial tissue
European Journal of Histochemistry, 2016 Cannabinoid receptors have been localized in the central and peripheral nervous system as well as on cells of the immune system, but recent studies on animal tissue gave evidence for the presence of cannabinoid receptors in different types of tissues ...
C. Fede +6 more
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Neural Plasticity, 2016 Neurocognitive effects of cannabinoids have been extensively studied with a focus on CB1 cannabinoid receptors because CB1 receptors have been considered the major cannabinoid receptor in the nervous system. However, recent discoveries of CB2 cannabinoid
Yong Li, Jimok Kim
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BMC Cancer, 2018 Background The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and CB2), comprising the endocannabinoid system ...
Mohammed I. Khan +7 more
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Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Pharmaceuticals, 2010 Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB2 receptor in the brain
Michelle Roche, David P Finn
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Journal of Lipid Research, 2008 Macrophage apoptosis is an important process in the pathophysiology of atherosclerosis. Oxidized low-density lipoproteins (OxLDL) are a major component of lesions and potently induce macrophage apoptosis.
Natalie E. Freeman-Anderson +5 more
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