Results 171 to 180 of about 21,687 (230)
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Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety
Amino Acids, 2002Evidence from several laboratories indicates that the anxiogenic effects of cholecystokinin (CCK) are mediated by CCKB receptors. However, it has been reported that CCKA receptors have been found in brain and CCKA antagonists have anxiolytic properties.
A M, Hernandez-Gómez +2 more
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Dopamine receptor elevation by cholecystokinin
Peptides, 1984High concentrations of cholecystokinin (CCK) in the striatum and limbic areas of the brain suggest that this peptide may influence dopaminergic transmission. Thus, the effect of CCK on dopamine D2 receptors in the striatum and nucleus accumbens of the rat brain both in vitro and in vivo (central and peripheral administration) was studied by determining
A, Dumbrille-Ross, P, Seeman
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Cholecystokinin-octapeptide fragments: Binding to brain cholecystokinin receptors
European Journal of Pharmacology, 1984Structural determinants of cholecystokinin octapeptide (CCK-8) binding to central nervous system receptors have been studied to assess the relative importance of the amino and the carboxyl end of the active peptide sequence, CCK-(26-33). The relative ability to inhibit equilibrium binding of [125I]CCK-33 to guinea pig cortical membranes was determined ...
M. Knight +5 more
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Cholecystokinin 1(A) Receptor Polymorphisms
Current Topics in Medicinal Chemistry, 2007Since the isolation and sequencing of cholecystokinin (CCK), considerable advances have been made in understanding the roles played by this peptide as a hormone and as a neuropeptide. CCK-1(A) and 2(B) receptor (R) cDNAs have been cloned; shortly thereafter, the naturally occurring CCK-1R gene-deficient rat (the Otsuka Long-Evans Tokushima Fatty (OLETF)
Kyoko, Miyasaka +2 more
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Journal of Surgical Research, 1995
It has been previously demonstrated that guinea pig pancreas possesses both cholecystokinin-A (CCK-A) receptors and CCK-B (gastrin) receptors. In contrast to guinea pig pancreas, it is not known whether CCK receptors in rat pancreas are CCK-A receptors, CCK-B (gastrin) receptors, or both.
W, Zhou, S P, Povoski, R H, Bell
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It has been previously demonstrated that guinea pig pancreas possesses both cholecystokinin-A (CCK-A) receptors and CCK-B (gastrin) receptors. In contrast to guinea pig pancreas, it is not known whether CCK receptors in rat pancreas are CCK-A receptors, CCK-B (gastrin) receptors, or both.
W, Zhou, S P, Povoski, R H, Bell
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2002
Abstract Cholecystokinin (CCK) is a peptide originally discovered in the gastrointestinal tract (Ivy and Oldberg 1928), but also found in high density in the mammalian CNS (Vanderhaeghen et al . 1975). This peptide, initially characterized as a 33 amino acid sequence, is present in a variety of biologically active molecular forms ...
Florence Noble, Bernard P Roques
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Abstract Cholecystokinin (CCK) is a peptide originally discovered in the gastrointestinal tract (Ivy and Oldberg 1928), but also found in high density in the mammalian CNS (Vanderhaeghen et al . 1975). This peptide, initially characterized as a 33 amino acid sequence, is present in a variety of biologically active molecular forms ...
Florence Noble, Bernard P Roques
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Phosphorylation and Desensitization of the Pancreatic Cholecystokinin-A Receptor
Digestion, 2009The eukaryotic cell uses a variety of mechanisms to protect itself from overstimulation. Among these mechanisms are processes involving the receptor, including uncoupling from G proteins and movement into cellular compartments. Here, we focus on mechanisms by which the pancreatic acinar cell protects itself from overstimulation through the ...
Willems, P.H.G.M. +3 more
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Cholecystokinin receptor subtypes and neuromodulation
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1989The sulfated octapeptide of cholecystokinin (CCK-8S) and CCK fragments have been administered to mice to determine the subtype and location of the CCK receptor that modulates the release of dopamine (DA) in brain. 1. Centrally (i.c.v.) or peripherally (s.c.) administered CCK-8S lowers DA release, and to a lesser extent, metabolism, in the neostriatum ...
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Ligands for Cholecystokinin A and Cholecystokinin B/Gastrin Receptors
1991Publisher Summary This chapter describes the radioligand binding assay methods used to identify and characterize the interaction of agents with the cholecystokinin-A (CCK-A) and CCK-B/gastrin receptor subtypes. The chapter also discusses the biochemical and pharmacological properties of nonpeptide CCK-A and CCK-B/gastrin antagonists, and their ...
Raymond S.L. Chang, Victor J. Lotti
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Cholecystokinin, Cholecystokinin-Receptor Antagonists and the Sphincter of Oddi
1991As a result of modern techniques like endoscopy, manometry, electromyography and hormonal assays, knowledge of the physiology and pathophysiology of sphincter of Oddi motility is now rapidly increasing. Opening of the sphincter of Oddi, once thought to be a simple passive event is a synchronized, dynamic action, involving both neural and humoral ...
J. B. M. Jansen, C. B. H. Lamers
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