Results 81 to 90 of about 17,995 (192)

Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cell Communication and Signaling, 2019
Background Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.
Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang, Jin Tao   +8 more
doaj   +1 more source

Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling

BMC Cancer, 2018
Background Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, but how its function affects ...
Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han, Guo-Hui Fu   +7 more
doaj   +1 more source

Goldfish phoenixin: (I) structural characterization, tissue distribution, and novel function as a feedforward signal for feeding-induced food intake in fish model

Frontiers in Endocrinology
Phoenixin (PNX) is a novel peptide with diverse functions mediated by the orphan receptor GPR173. It also plays a role in appetite control, but the effect is not consistent across species and the mechanisms involved are still unclear. Using goldfish as a
Xiangfeng Qin, Cheng Ye, Ying Wai Chan, Anderson O. L. Wong   +3 more
doaj   +1 more source

Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability

Molecular Metabolism
Objectives: The brain mobilizes glucose in emergency situations such as hypoglycemia as well as during day-to-day physiology such as fasting. While most hypothalamic neuronal populations that contribute to glucose mobilization also contribute to other ...
Jiaao Su, Abdullah Hashsham, Nandan Kodur, Carla Burton, Amanda Mancuso, Anjan Singer, Jennifer Wloszek, Abigail J. Tomlinson, Warren T. Yacawych, Jonathan N. Flak, Kenneth T. Lewis, Lily R. Oles, Hiroyuki Mori, Nadejda Bozadjieva-Kramer, Adina F. Turcu, Ormond A. MacDougald, Martin G. Myers, Alison H. Affinati   +17 more
doaj   +1 more source

Establishment of a mouse model for injury-induced scar formation and the accompanying chronic pain: Comprehensive microarray analysis of molecular expressions in fibrosis and hyperalgesia

Molecular Pain, 2019
Background Surgery is often accompanied by scar formation, which results in a pathological state called fibrosis. Fibrosis is characterized by the excess deposition of extracellular matrix molecules in the connective tissue, leading to tissue contracture
Yuqiang Li, Hiroki Iida, Koji Kimata, Lisheng Zhuo, Akinobu Ota, Shinya Kimura, Xiaojian Yin, Masataka Deie, Takahiro Ushida   +8 more
doaj   +1 more source

Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex

eLife
Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice.
Hao Li, Jingyu Feng, Mengying Chen, Min Xin, Xi Chen, Wenhao Liu, Liping Wang, Kuan Hong Wang, Jufang He   +8 more
doaj   +1 more source

Corrigendum to “Single-chain fragment variable antibody targeting cholecystokinin-B receptor for pain reduction” [Neurobiol. Pain 10 (2021) 100067]

Neurobiology of Pain, 2023
K.N. Westlund, M.A. Montera, A.E. Goins, S.R.A. Alles, M. Afaghpour-Becklund, R. Bartel, R. Durvasula, A. Kunamneni   +7 more
doaj   +1 more source

Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway

Advanced Science
The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development ...
Xue Liu, Xing Liu, Yunpeng Liu, Anxiong Long, Wei Liu, Shiyun Sun, Shuaibing Lu, Xianxian Wu, Xiaodi Jia, Pedro A Jose, Qiang Wei, Xiaoliang Jiang, Haizeng Zhang, Zhiwei Yang   +13 more
doaj   +1 more source

Gastrin/Cholecystokinin Type B Receptor [PDF]

, 2020
openaire   +1 more source

Cholecystokinin B receptor (CCKBR; CCK2R) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source