Results 151 to 160 of about 55,630 (278)
Safety and tolerability of bosentan in the management of pulmonary arterial hypertension
Drug Design, Development and Therapy, 2009 Kari E Roberts, Ioana R PrestonPulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts, USAAbstract: Endothelin receptor antagonism has emerged as an important therapeutic approach in pulmonary arterial hypertension (PAH).
Kari E Roberts, Ioana R Preston
doaj
Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies
The Journal of Physiology, EarlyView.Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu +3 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Emmanuel Ifeanyi Obeagu
wiley +1 more source
An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle
, 2007 Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive Ca²⁺ stores.
Kinnear, Nicholas P.
core
Progress in mechanistic and clinical translational research of endothelin A receptor antagonists in the treatment of diabetic kidney disease: a narrative review. [PDF]
Front Endocrinol (Lausanne)Li M +6 more
europepmc +1 more source
Advanced Sensor Research, Volume 5, Issue 7, July 2026.Breathomics is established as a non‐invasive diagnostic strategy by combining volatile organic compound biomarkers, nanomaterial‐based sensor arrays, and AI‐driven classification. Key diseases, sensing materials, and analytical challenges are critically compared, revealing how portable, data‐enabled breath platforms are moving toward clinically useful ...
Anesu Nyabadza +3 more
wiley +1 more source
, 2008 Atherosclerosis is the primary ischaemic vascular condition underlying a majority of cardiovascular disease related deaths. Endothelin-1 is a vasoactive peptide agent upregulated in atherosclerosis and in conjunction with its G protein-coupled receptors ...
Peter Little AM (18043684) +2 more
core
Targeting Peptidergic Systems for Melanoma Treatment. [PDF]
Cancers (Basel)Sánchez ML, Mehboob R, Coveñas R.
europepmc +1 more source
Natural History of Chronic Kidney Disease in Sickle Cell Disease
American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley +1 more source
Role for endothelin-1 in cardiometabolic dysfunction with intermittent hypoxia. [PDF]
Function (Oxf)Gonsalves AM +3 more
europepmc +1 more source