Results 211 to 220 of about 93,761 (300)

The Endothelial Glycocalyx: The First Line of Defense in the Prevention and Treatment of Kidney Diseases. [PDF]

Kidney Med
Yuan X, Jia M, Zhou L, Hou G, Zhang B, Ouyang X, Huang Y.   +6 more
europepmc   +1 more source

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

Endothelin Receptor Antagonists for the Treatment of Hypertension: Recent Data from Clinical Trials and Implementation Approach. [PDF]

Curr Cardiol Rep
Manickavasagar R, Krishnan A, Azzam O, Schlaich MP.   +3 more
europepmc   +1 more source

Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 137-151, January 2026.
ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi, A. C. Ericson, A. Shikhan, L. Larsson, T. Berglundh   +4 more
wiley   +1 more source

Matching-adjusted indirect comparison of kidney function in patients with immunoglobulin A nephropathy treated with nefecon or sparsentan. [PDF]

J Comp Eff Res
Ngai C, Patel M, Kopiec A, Fu S, Hummel N.   +4 more
europepmc   +1 more source

Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology

Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.
ABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to ...
Ting Liao, Rui Luo, Ying Deng, Hongqiu Yang, Yu Du   +4 more
wiley   +1 more source

Successful Clazosentan Therapy for Subarachnoid Hemorrhage after Coil Embolization of Ruptured Posterior Cerebral Artery Aneurysm in a Patient with Moyamoya Disease: A Case Report. [PDF]

NMC Case Rep J
Uchino H, Sugiyama T, Hokari M, Yamaguchi Y, Osanai T, Fujimura M.   +5 more
europepmc   +1 more source

Acute Rejection With DSA‐Negative Severe Microvascular Inflammation in a Kidney Transplant Recipient With an Isolated DPB1*04‐Mismatch Successfully Stabilised With Daratumumab

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Microvascular inflammation (MVI) in kidney allografts in the absence of detectable donor‐specific anti‐HLA antibodies (DSA) is increasingly recognised as a cause of premature graft failure following kidney transplantation. Potential mechanisms include NK cell alloreactivity mediated by recognition of mismatched HLA class I molecules (missing ...
Laura Knödl, Maike Büttner‐Herold, Markus Götz, Markus Luber, Bernd Spriewald, Michael Oellerich, Julia Beck, Bernhard Banas, Daniel Zecher   +8 more
wiley   +1 more source

The role of orexin A in the pathogenesis of ischaemic stroke at high altitude

Experimental Physiology, Volume 111, Issue 1, Page 257-269, 1 January 2026.
Schematic illustration of the experimental design. This study investigated the role of Orexin A in the pathogenesis of ischemic stroke at high altitude. Abstract Orexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression.
Minxia Zhu, Xu Guo, Jing Guo, Zhaojun Zhang, Kexin Zhang, Yaqi Lei, Yuhe Wang, Haoshuang Zhan   +7 more
wiley   +1 more source

Pulmonary Hypertension in Systemic Lupus Erythematosus: Current Evidence and Future Directions. [PDF]

Cureus
Santacruz JC, Mantilla MJ, Pulido S, Agudelo C, Naranjo JA, Vergara OV, Londono J.   +6 more
europepmc   +1 more source