Results 231 to 240 of about 55,630 (278)

Histochemical Studies on Endothelin and the Endothelin-A Receptor in the Hypothalamus

Journal of Cardiovascular Pharmacology, 1998
By use of a rabbit polyclonal antibody specific to the endothelin-A (ETA) receptor, we analyzed the distribution of neurons containing ETA receptors in rat brain. Almost all A1-A7 noradrenergic neurons, A8-A16 and retinal amacrine (A17) dopaminergic neurons (except the A15 group), and C3 adrenergic neurons contained ETA receptors.
H, Yamada, K, Kurokawa
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Endothelin receptor antagonists

World Journal of Urology, 2005
Hormone refractory prostate cancer remains true to its middle name: it is largely refractory to attempts to delay its progression. New targets and new therapies are demanded. Through a review of the available literature on endothelin and several preclinical observations, the endothelin axis has emerged as one such target.
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Endothelin Receptor Antagonists

2013
Three pathways have been identified in the pathogenesis of pulmonary arterial hypertension (PAH): the endothelin (ET), nitric oxide (NO) and prostacyclin pathways. These pathways represent the targets of approved PAH therapies and their discovery has facilitated significant progress in the understanding and treatment of PAH.
Martine, Clozel, Alessandro, Maresta, Marc, Humbert   +2 more
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Endothelin and Endothelin Receptor Antagonists in Heart Failure

Congestive Heart Failure, 2002
Endothelin (ET) is a recently discovered 21‐amino acid peptide that has potent physiologic and pathophysiologic effects that appear to be involved in the development of heart failure. These include effects on arterial smooth muscle cells that cause intense peripheral vasoconstriction and stimulation of cardiac myocytes and fibroblasts.
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Endothelin Receptor Antagonism

1995
Following the original report by Yanagisawa et al. (1988) more than 7 years ago, compelling evidence that ET plays an important role in the local regulation of smooth muscle tone and cell growth has been reported. In addition, many studies point to a significant role for endothelin in nonvascular function. The investigation of the endothelin system has
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Endothelins and their receptors in embryo implantation

Journal of Cellular Biochemistry, 2019
AbstractAs a critical stage of pregnancy, the implantation of blastocysts into the endometrium is a progressive, excessively regulated local tissue remodeling step involving a complex sequence of genetic and cellular interplay executed within an optimal time frame. For better understanding the causes of infertility and, more importantly, for developing
Aynaz Mihanfar, Aydin Raei Sadigh, Amir Fattahi, Zeinab Latifi, Mahsa Hasanzadeh‐Moghadam, Mahrokh Samadi, Laya Farzadi, Kobra Hamdi, Aliyeh Ghasemzadeh, Hamid Reza Nejabati, Mohammad Nouri   +10 more
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Endothelin, endothelin receptors, and endothelin antagonists.

Current opinion in nephrology and hypertension, 1995
Endothelin is a peptide with potent biologic effects in vascular and nonvascular cells. Its effects are mediated by two receptors, ETA and ETB, and possibly also by a third receptor, ETC. In vascular smooth muscle cells, endothelin causes profound contraction and also has proliferative effects, mainly through activation of ETA but also through ETB ...
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Desensitization of Human Endothelin A Receptor

Journal of Cardiovascular Pharmacology, 1993
The response of G-protein-coupled receptors is modulated by homologous desensitization. Because endothelin A receptor (ETA) plays a part in vasoconstriction, the extent of desensitization and resensitization of endothelin responsiveness was studied.
C, Cyr, R M, Kris
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Characterization of Endothelin Receptor Subtypes

Journal of Cardiovascular Pharmacology, 1991
Scatchard-plot analysis of [125I]ET-1 and [125I]ET-3 binding to rat lung membranes exhibited almost the same Kd values whereas the concentration of the binding sites of ET-1 is approximately four times higher than that of ET-3. This result suggests the presence of at least two distinct subtypes of ET receptors: an ET-1-specific type and an ET-3 ...
H, Miyazaki, M, Kondoh, H, Watanabe, T, Shibata, Y, Masuda, K, Murakami   +5 more
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Effect of castration on endothelin receptors

Clinical Science, 2002
Endothelin (ET) plays a pivotal role in the pathogenesis of cell growth disorders such as cancer. Atrasentan (ABT-627), a selective antagonist for the ET receptor A (ETA), has shown benefit in controlling disease progression in men with hormone refractory prostate cancer who have undergone aggressive hormone ablation therapy.
Robert J, Padley, Douglas B, Dixon, J Ruth, Wu-Wong   +2 more
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