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Endothelin Receptor Antagonists - An Overview
Current Medicinal Chemistry, 2002In thirteen years since the appearance of Endothelin (ET) on the international scene, possibility of its involvement in a variety of diseases has attracted the attention of medicinal chemists in search of novel therapeutics for various cardiovascular diseases (CVDs).
Falguni, Dasgupta +2 more
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Internalization of Type-A Endothelin Receptor
Journal of Cardiovascular Pharmacology, 2000Endothelins (ETs) are 21 amino acid peptides which bind to ET(A)- and ET(B)-receptors to evoke diverse physiological responses. This report studies the internalization of ET(A)-receptor in Chinese hamster ovary (CHO) cells which were stably transfected with ET(A)-receptor cDNA.
J, Wang +3 more
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Endothelins and sarafotoxins: Receptor heterogeneity
International Journal of Biochemistry, 19941. Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of 21-amino-acid peptides comprising at least eight isoforms. 2. ET exerts multiple pharmacological effects through its receptors. 3. This review summarizes the observations and findings pointing to the existence of receptor subtypes and leading to their identification. 4.
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[Molecular biology of endothelins and endothelin receptors].
Nihon rinsho. Japanese journal of clinical medicine, 1993Endothelin (ET) was initially identified as a potent vasoconstrictor peptide with 21 amino-acid residues, produced by cultured porcine aortic endothelial cells. Cloning of the ET genes revealed the existence of three isopeptides, ET-1, ET-2 and ET-3, which are widely distributed in a variety of tissues and possess wide variety of pharmacological ...
H, Arai +4 more
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PATHOPHYSIOLOGY OF ENDOTHELIN IN THE CARDIOVASCULAR SYSTEM
Annual Review of Physiology, 1999Takashi Miyauchi
exaly